Mucociliary clearance following segmental tracheal reversal

The Laryngoscope
P R DelaereL Feenstra

Abstract

Ciliated tracheal epithelium is arranged in a polarized pattern oriented according to the inferior-superior axis of the trachea and is responsible for the transport of mucus toward the larynx. In this study, ciliary beat orientation and the influence of external factors on mucociliary clearance direction were studied in rabbit inverted cervical tracheas. The animals displayed normal respiration postoperatively. After 16 weeks, airway clearance was studied by observation of the movement of silicone particles placed in the inverted segment and in normal parts of the ciliated epithelium. Cilia exhibited unidirectional and coordinated movement within inverted tracheal segments. As shown by the direction of effective flow produced by beating cilia and by scanning electron microscopy, the cilia in the inverted segment beat in the opposite direction from the cilia in the remainder of the trachea. This study demonstrated that ciliary orientation is irreversibly determined, but the reversal of ciliary beating within the cervical trachea had no adverse effects on the survival of the animals.

References

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Nov 1, 1970·Acta Oto-laryngologica·B Drettner, C E Lindholm
Oct 1, 1994·Archives of Otolaryngology--head & Neck Surgery·P R DelaereL Feenstra
Mar 1, 1994·The Annals of Otology, Rhinology, and Laryngology·P R DelaereL Feenstra
Jun 1, 1994·The Laryngoscope·P R DelaereL Feenstra

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Citations

Feb 24, 1998·The Laryngoscope·P R DelaereR Hermans
Nov 30, 1999·Plastic and Reconstructive Surgery·P DelaereR Hermans
Jun 13, 2003·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Cahide Ortuğ
Jul 16, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Altay AteşpareÖner Çelik
Feb 25, 1999·The Annals of Otology, Rhinology, and Laryngology·P R DelaereR Hermans
Aug 5, 2017·The Laryngoscope·Elizabeth F MaughanMartin J Elliott
Feb 6, 2018·Respiratory Research·Takuya TsujiKoichi Omori
May 20, 2021·Journal of Tissue Engineering and Regenerative Medicine·Ryosuke NakamuraKoichi Omori

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