Mucolipin controls lysosome exocytosis in Dictyostelium

Journal of Cell Science
Wanessa C LimaPierre Cosson

Abstract

Mucolipidosis type IV is a poorly understood lysosomal storage disease caused by alterations in the mucolipin lysosomal Ca(2+) channel. In this study, we generated mucolipin-knockout Dictyostelium cells, and observed that lysosome exocytosis was markedly increased in these cells compared with wild-type cells. In addition, mucolipin-knockout cells were more resistant to Ca(2+) deprivation, and the Ca(2+) concentration in their secretory lysosomes was decreased, suggesting that mucolipin transfers Ca(2+) ions from the cytosol to the lumen of secretory lysosomes. We speculate that mucolipin attenuates the fusogenic effect of local cytosolic increases in Ca(2+) by dissipating them into the lumen of lysosomal compartments.

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Citations

Feb 13, 2014·PloS One·Wanessa C LimaPierre Cosson
Nov 27, 2015·The American Journal of Pathology·Yulia GrishchukSusan A Slaugenhaupt
Sep 10, 2014·Acta Neuropathologica Communications·Yulia GrishchukSusan A Slaugenhaupt
Dec 4, 2014·Cell Calcium·Kartik VenkatachalamMichael X Zhu
Oct 29, 2013·Biochimica Et Biophysica Acta·S J AnnesleyP R Fisher
Jan 17, 2015·Cell Calcium·Sandip Patel, Xinjiang Cai
May 14, 2016·Journal of Cell Science·Aurélie GuehoFrançois Letourneur
Apr 21, 2017·Journal of Cell Science·Peter A ThomasonRobert H Insall
May 18, 2018·Journal of Neurochemistry·Lauren C Boudewyn, Steven U Walkley
Oct 13, 2018·Canadian Journal of Physiology and Pharmacology·Yan YeJonathan D Geiger
Jan 23, 2018·Frontiers in Immunology·Joe Dan DunnThierry Soldati
Jun 18, 2020·International Journal of Molecular Sciences·Dawid JaślanChristian Grimm
Jan 24, 2020·BMC Biology·Fu-Sheng ChangCatherine Pears
Nov 8, 2020·Applied and Environmental Microbiology·Yijing ShiLongfei Shu

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