Mucormycosis extending from the surgical wound to the transplanted kidney: case report and literature review

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
Liang ZhaoLong-shan Liu

Abstract

Mucormycosis is an opportunistic, life-threatening infection in organ transplant recipients. We report a case of surgical wound mucormycosis that extended to a transplanted kidney. The patient was a 59-year-old man who underwent a donation-after-cardiac-death kidney transplant 10 years after receiving a liver transplant. On day 10 after the kidney transplant, he presented with cutaneous and subcutaneous tissues necrotizing at his right lower abdominal surgical wound. The necrotic tissue biopsy and laboratory culture showed different causes, while a polymerase chain reaction quickly identified the causative fungus at the species level. Although the combination therapy consisted of immunosuppressant withdrawal, intravenous Liposome AmB, and aggressive surgical debridement; unfortunately, the cutaneous mucormycosis invaded his transplanted kidney, and the patient was given a graft nephrectomy and subsequent hemodialysis. We review the literature and conclude that mucormycosis in organ transplant recipients is a rare and extremely severe complication. Polymerase chain reaction provides a rapid and accurate diagnostic technique for species identification. Early effective antifungal therapy combined with aggressive surgical intervent...Continue Reading

References

Apr 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R Perfect
Jul 16, 2005·Clinical Microbiology Reviews·Brad SpellbergAshraf Ibrahim
Aug 5, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maureen M RodenThomas J Walsh
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·R N GreenbergR Hare
Feb 4, 2006·Journal of Clinical Microbiology·Patrick SchwarzEric Dannaoui
Mar 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jo-Anne H van BurikDimitrios P Kontoyiannis
Mar 29, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M ChayakulkeereeJ R Perfect
Jul 10, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Steven GabardiStefan G Tullius
Mar 28, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Ingrid StelzmuellerHugo Bonatti
Jul 17, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A V PageW C Liles
May 14, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brad SpellbergAshraf S Ibrahim
Sep 17, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A Skiada, G Petrikkos

❮ Previous
Next ❯

Citations

Oct 1, 2012·Journal of Nephropathology·Krishan L Gupta, Aakriti Gupta
Jun 22, 2014·AJR. American Journal of Roentgenology·Punit SharmaRakesh Kumar
Dec 1, 2012·Clinical Kidney Journal·Krishan L GuptaVinay Sakhuja

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.