PMID: 9539557Apr 16, 1998Paper

Mucosa-adhesive water-soluble polymer film for treatment of acute radiation-induced oral mucositis

International Journal of Radiation Oncology, Biology, Physics
M OguchiS Sone

Abstract

To examine the usefulness and safety of a mucosa-adhesive water-soluble polymer film (AD film) containing anesthetics and antibiotics for the treatment of acute radiation-induced oral mucositis. To prepare AD films, 600 mg of hydroxy-propyl-cellulose was dissolved in ethyl alcohol, and mixed with a solution containing tetracaine, ofloxacine, miconazole, guaiazulene, and triacetin. The gel obtained was dried to form 30 translucent round sheets (20 mg per sheet) of 7.5 cm in diameter and 0.2 mm in thickness. The AD film showed excellent adhesive and coating properties when placed on wet oral mucosa. From 1993 to 1994, we used the AD film in 25 patients with acute radiation-induced oral mucositis, in an attempt to alleviate their pain and prevent secondary oral infection. All patients had received definitive radiotherapy for oral carcinoma. Intensity and duration of oral pain from mucositis, relief rates at rest and while eating, and presence of bacterial and/or fungal infection were compared with those of 27 patients treated with topical anesthetics (viscous lidocaine, Xylocaine and/or general systemic analgesics from 1990 to 1992 (NonAD Group). The intensity of oral pain was the same in the two groups. The mean duration of pain ...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·N A JanjanA Pahule
Mar 1, 1991·Oral Surgery, Oral Medicine, and Oral Pathology·G BarkerB Barker
Jun 1, 1988·Oral Surgery, Oral Medicine, and Oral Pathology·B Rodu, C M Russell
Feb 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J B Epstein, F L Wong
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·R MeredithJ Lee

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Citations

May 21, 2013·Der Schmerz·H Bornemann-CimentiA Sandner-Kiesling
Jun 15, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Joel B EpsteinMichael T Brennan
Dec 21, 2000·Current Oncology Reports·J T Johnson
Feb 19, 2002·International Journal of Radiation Oncology, Biology, Physics·Dosia AntonadouNicolas Throuvalas
Jul 3, 2003·The Lancet Infectious Diseases·J Peter DonnellyR Paul Symonds
Nov 5, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Makoto TanabeKeizo Inoue
Sep 10, 2013·International Journal of Pharmaceutical Investigation·Rachna KumriaAnroop B Nair
Jun 25, 2009·European Journal of Pharmacology·Shinichi WatanabeHiroaki Araki
Oct 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Daniela AlterioRoberto Orecchia
Feb 11, 2014·Drug Development and Industrial Pharmacy·Rachna KumriaBandar E Al-Dhubiab
Aug 30, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tamer GunesTakashi Hashimoto
Feb 19, 2000·The Journal of the American Dental Association·M PadillaR L Merrill
Sep 22, 2000·Current Review of Pain·W Carl, J Havens
Jan 30, 2013·Journal of Pharmacological Sciences·Shinichi WatanabeHiroaki Araki
Aug 23, 2008·Drug Development and Industrial Pharmacy·G S AsaneY Madhusudan Rao
Apr 27, 2004·Cancer·Edward B RubensteinUNKNOWN International Society for Oral Oncology
Aug 6, 2010·The Cochrane Database of Systematic Reviews·Jan E ClarksonStefan Meyer
Jul 23, 1999·Current Opinion in Oncology·D E Peterson
Mar 29, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Tessa LefebvrePhilip Debruyne
Aug 25, 2016·Expert Opinion on Drug Delivery·Michelle Franz-MontanEneida de Paula
Jan 22, 2013·Advanced Healthcare Materials·Sundar P AuthimoolamThomas D Dziubla
Jul 25, 2021·Materials·Dorota KidaBożena Karolewicz

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