Mucosa-associated invariant T cells in malignancies: a faithful friend or formidable foe?

Cancer Immunology, Immunotherapy : CII
S M Mansour HaeryfarPatrick T Rudak

Abstract

Mucosa-associated invariant T (MAIT) cells are a subset of innate-like T lymphocytes known for their ability to respond to MHC-related protein 1 (MR1)-restricted stimuli and select cytokine signals. They are abundant in humans and especially enriched in mucosal layers, common sites of neoplastic transformation. MAIT cells have been found within primary and metastatic tumors. However, whether they promote malignancy or contribute to anticancer immunity is unclear. On the one hand, MAIT cells produce IL-17A in certain locations and under certain circumstances, which could in turn facilitate neoangiogenesis, intratumoral accumulation of immunosuppressive cell populations, and cancer progression. On the other hand, they can express a potent arsenal of cytotoxic effector molecules, NKG2D and IFN-γ, all of which have established roles in cancer immune surveillance. In this review, we highlight MAIT cells' characteristics as they might pertain to cancer initiation, progression, or control. We discuss recent findings, including our own, that link MAIT cells to cancer, with a focus on colorectal carcinoma, as well as some of the outstanding questions in this active area of research. Finally, we provide a hypothetical picture in which MA...Continue Reading

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Citations

Apr 18, 2018·Immunological Reviews·James L ReadingSergio A Quezada
Apr 19, 2018·Journal of Leukocyte Biology·Patrick T RudakS M Mansour Haeryfar
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Dec 18, 2020·PLoS Pathogens·S M Mansour Haeryfar
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Apr 15, 2021·Cell Reports·Patrick T RudakS M Mansour Haeryfar
May 1, 2021·Viruses·Eirini D TseligkaFrancesco Negro
Jul 2, 2021·Cancer Immunology Research·Benjamin RufTim F Greten

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