PMID: 2504053Aug 1, 1989Paper

Mucosal arachidonate metabolism and intestinal ischemia-reperfusion injury

The American Journal of Physiology
M J ManginoJ Turk

Abstract

Mucosal arachidonic acid metabolism was examined after 3 h of ischemia and 1 h of reperfusion in isolated ileal segments in the dog. The cyclooxygenase products thromboxane B2, 6-ketoprostaglandin F1 alpha, and prostaglandin E2 increased by 365%, 97%, and 158%, respectively, after ischemia and reperfusion but were not altered after 3 h of ischemia alone. The potent chemotactic lipoxygenase product leukotriene B4 (LTB4) increased by 687% after ischemia and reperfusion and was not affected by ischemia without reperfusion. In addition, tissue production of the thiol ether leukotrienes (LTC4, LTD4, and LTE4) increased threefold after ischemia and reperfusion. Quantitation of regionally isomeric hydroxy acids produced from arachidonate revealed a 300% increase in 12-hydroxyeicosatetraenoate (12-HETE) after intestinal ischemia and reperfusion without a change in other isomers (15-HETE and 5-HETE). Stereochemical analysis of 12-HETE demonstrated exclusive synthesis of the S-enantiomer. A significant and time-dependent decrease in intestinal blood flow also occurred during reperfusion. Administration of the dual cyclooxygenase-lipoxygenase synthesis inhibitor BW755C (1 mg/kg ia) did not alter time-dependent decreases in blood flow and ...Continue Reading

Citations

Jan 18, 2008·World Journal of Gastroenterology : WJG·Arda DemirkanMehmet Melli
Jun 6, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Courtney C KurtzHannah V Carey
May 23, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Heitham T HassounBruce C Kone
Dec 6, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lei ZouBruce C Kone

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