Mucosal-Associated Invariant T Cells in Chronic Inflammatory Liver Disease

Seminars in Liver Disease
Fabian J Bolte, Barbara Rehermann

Abstract

The broadening field of microbiome research has led to a substantial reappraisal of the gut-liver axis and its role in chronic liver disease. The liver is a central immunologic organ that is continuously exposed to food and microbial-derived antigens from the gastrointestinal tract. Mucosal-associated invariant T (MAIT) cells are enriched in the human liver and can be activated by inflammatory cytokines and microbial antigens. In chronic inflammatory liver disease, MAIT cells are depleted suggesting an impaired MAIT cell-dependent protection against bacterial infections.

Citations

Nov 15, 2018·Frontiers in Immunology·Wenyong HuangYifang Gao
Feb 23, 2019·Frontiers in Immunology·Mikhaïl A Van HerckLuisa Vonghia
Aug 9, 2020·Frontiers in Immunology·Yongyan Chen, Zhigang Tian
Sep 5, 2020·World Journal of Gastroenterology : WJG·Hong XueZhao-Lian Bian
Sep 30, 2018·Gastroenterology·Barbara Rehermann, Robert Thimme
Mar 12, 2021·Alcoholism, Clinical and Experimental Research·Min GuDavid A Welsh
May 17, 2021·Current Opinion in Virology·Carolina ChialeMichael D Robek
Jun 4, 2021·Hepatic Medicine : Evidence and Research·Irene PerezNeeral L Shah

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