Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease

Immunology
Timothy Sc Hinks

Abstract

Mucosal-associated invariant T (MAIT) cells are a novel class of innate-like T cells, expressing a semi-invariant T-cell receptor (TCR) and able to recognize small molecules presented on the non-polymorphic MHC-related protein 1. Their intrinsic effector-memory phenotype, enabling secretion of pro-inflammatory cytokines, and their relative abundance in humans imply a significant potential to contribute to autoimmune processes. However, as MAIT cells were unknown until recently and specific immunological tools were unavailable, little is known of their roles in disease. Here I review observations from clinical studies and animal models of autoimmune and immune-mediated diseases including the roles of MAIT cells in systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease and airways diseases. MAIT cell deficiencies are frequently observed in peripheral blood, and at sites of disease such as the airways in asthma. However, MAIT cells have a specific sensitivity to suppression by therapeutic corticosteroids that may confound many of these observations, as may the tendency of the surface marker CD161 to activation-induced down-regulation. Nonetheless, the dependence on bacteria for the devel...Continue Reading

References

Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Oct 23, 1997·Biochemical and Biophysical Research Communications·H YamaguchiK Hashimoto
Feb 27, 1999·Current Opinion in Immunology·V M BraudA J McMichael
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J MileyLonnie Lybarger
Mar 22, 2005·Microbes and Infection·Emmanuel TreinerOlivier Lantz
Apr 2, 2005·The Journal of Biological Chemistry·Shouxiong HuangTed H Hansen
May 20, 2005·The New England Journal of Medicine·Thomas R TalbotMarie R Griffin
Oct 11, 2005·Current Opinion in Immunology·Ludvig M Sollid, Bana Jabri
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Izumi KawachiSusan Gilfillan
Aug 1, 2006·Nature Immunology·J Ludovic CroxfordTakashi Yamamura
Oct 3, 2006·Current Opinion in Immunology·Dale T Umetsu, Rosemarie H Dekruyff
Nov 15, 2006·The Journal of Experimental Medicine·Silvia Schnyder-CandrianBruno Schnyder
Feb 20, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David I Bernstein, David B Allen
Feb 23, 2007·The New England Journal of Medicine·Peter M A CalverleyUNKNOWN TORCH investigators
Apr 6, 2007·The New England Journal of Medicine·Pandurangan VijayanandRatko Djukanovic
May 15, 2007·Nature·Tarjei S MikkelsenKerstin Lindblad-Toh
Apr 1, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Chun Kwok WongChristopher Wai Kei Lam
Apr 30, 2008·The Journal of Experimental Medicine·Shouxiong HuangTed H Hansen
Nov 7, 2008·The New England Journal of Medicine·Ratko Djukanovic, Stephan D Gadola
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·José C CrispínGeorge C Tsokos
Dec 23, 2008·Mucosal Immunology·I J Fuss, W Strober
Mar 13, 2009·PLoS Biology·Emmanuel MartinOlivier Lantz
May 1, 2009·Arthritis and Rheumatism·Ji YangMing Li
May 16, 2009·Nature Reviews. Immunology·Joan Goverman
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Eva BillerbeckPaul Klenerman
Jun 29, 2010·Nature Immunology·Lionel Le BourhisOlivier Lantz
Dec 31, 2010·Molecular Immunology·Philippe GeorgelSeiamak Bahram
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Tina HerbstNicola L Harris
May 7, 2011·The Journal of Allergy and Clinical Immunology·Anna LluisBianca Schaub
Jun 30, 2011·International Immunology·Yusei MiyazakiTakashi Yamamura
Aug 25, 2011·Nature Reviews. Rheumatology·Jose U Scher, Steven B Abramson

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Citations

Oct 21, 2016·Nature Reviews. Rheumatology·Mark A ExleyBen Mulhearn
Jul 31, 2016·Annals of the Rheumatic Diseases·Karlijn DebusschereDirk Elewaut
Nov 16, 2016·American Journal of Respiratory and Critical Care Medicine·Kristian Riesbeck
Nov 7, 2017·International Reviews of Immunology·Vijay Kumar, Ali Ahmad
Nov 29, 2017·Respiratory Research·Mariann SzabóPéter Engelmann
May 11, 2017·American Journal of Respiratory Cell and Molecular Biology·Enrico HefflerSebastiano Gangemi
Sep 22, 2017·International Reviews of Immunology·Carolina SchäferLeandro J Carreño
Dec 22, 2017·Journal of Gastroenterology and Hepatology·Toru SetsuShuji Terai
Feb 7, 2018·American Journal of Respiratory and Critical Care Medicine·Fernando J MartinezJadwiga A Wedzicha
Jun 17, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Naomi TsurikisawaHiroshi Saito
Jun 30, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sothea TouchUNKNOWN MetaCardis Consortium
Sep 20, 2018·Clinical and Experimental Immunology·J R FergussonL J Walker
Nov 3, 2017·Journal of the American Society of Nephrology : JASN·Jan-Eric TurnerUlf Panzer
Sep 3, 2016·Clinical & Translational Immunology·Ayako KuriokaChristian B Willberg
Feb 2, 2018·Clinical Microbiology Reviews·Fabián E DíazAlexis M Kalergis
Sep 25, 2019·Chemistry, an Asian Journal·Shoji KobayashiAraki Masuyama
Oct 4, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mei ZhangYongjian Wu
Dec 18, 2019·Rheumatology·Charles CassiusHélène Le Buanec
Feb 8, 2020·Immunity, Inflammation and Disease·Matty L TerpstraSuzanne E Geerlings
Jul 12, 2020·European Journal of Immunology·Matty L TerpstraFrederike J Bemelman
Apr 21, 2017·Journal of Applied Toxicology : JAT·Adam C SoloffPatricia A Fair
Jul 21, 2017·Scandinavian Journal of Immunology·A MekinianB Gaugler
Jun 27, 2018·Frontiers in Immunology·Asako ChibaSachiko Miyake
Jun 5, 2020·ERJ Open Research·Gareth M Hynes, Timothy S C Hinks
Sep 14, 2018·Frontiers in Immunology·Chiaki Iwamura, Toshinori Nakayama
Nov 22, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Timothy S C HinksErwin W Gelfand
Apr 10, 2018·The Journal of Clinical Investigation·Antiopi VareliasGeoffrey R Hill
Aug 6, 2017·Current Diabetes Reports·Sothea TouchSébastien André
Jul 17, 2018·Frontiers in Immunology·Céline MortierDirk Elewaut
Jun 17, 2020·Frontiers in Immunology·Timothy S C Hinks, Xia-Wei Zhang
Jun 9, 2020·Frontiers in Immunology·Stuart P BerzinsJason Kelly
Jul 19, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Matyas MeggyesLaszlo Szereday
Jul 22, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christoph SchultheißMascha Binder

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Methods Mentioned

BETA
transgenic
biopsies
biopsy

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