Mucosal dysplasia of gallbladder: isolated and adjacent lesions to carcinoma

Japanese Journal of Cancer Research : Gann
H Yamagiwa

Abstract

Isolated dysplasia was found in 46 (54 lesions) of 2,027 gallbladders, which were histologically studied by serial step sectioning. Average age of patients was 63.8 with a male-to-female ratio of 1 to 3. These lesions, excluding polypoid lesions of adenoma, were located most frequently in the fundus and body, showing flat granular or irregular appearance. As to the size, 68.6% were smaller than 1 cm in diameter (89% were smaller than 2 cm). Most mild dysplasias were found in small lesions less than 0.5 cm in diameter and moderate ones in lesions of less than 1.5 cm, though severe dysplasias were found in various sizes. Gallstones were found in 86.9% of the cases with dysplasia, and intestinal metaplasia and pseudopyloric gland metaplasis were found in 80.4% and 100%. Dysplasia adjacent to carcinoma was found in 46 of 110 cases (41.8%), and this change was frequently found in lesions at the early stage and well-differentiated carcinoma. It seems that mucosal damage caused by a stone and subsequent inflammation may be important in the histogenesis of intestinal metaplasia and dysplasia.

References

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Citations

Feb 16, 2008·Journal of Hepato-biliary-pancreatic Surgery·Masaru MiyazakiUNKNOWN Japan Society of Clinical Oncology
Sep 29, 2011·Pathology International·Alberto E Paniz MondolfiNeil D Theise
Jun 16, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aram F HezelAndrew X Zhu
Mar 5, 2014·The Journal of Surgical Research·Leonardo SolainiHemant M Kocher
May 28, 2013·Cirugía española·Helmut Alfredo Segovia Lohse, Osmar Manuel Cuenca Torres
Aug 23, 2012·American Journal of Clinical Pathology·Andrew A Renshaw, Edwin W Gould
Mar 25, 2009·Surgical Oncology Clinics of North America·Srinevas K Reddy, Bryan M Clary
May 26, 2006·Journal of Surgical Oncology·Iván RoaJuan Roa
Mar 20, 2015·Journal of Hepato-biliary-pancreatic Sciences·Masaru MiyazakiTadahiro Takada
Oct 15, 2008·São Paulo Medical Journal = Revista Paulista De Medicina·José Eduardo Vasconcelos FernandesSansom Henrique Bromberg
Apr 30, 2013·Cancer Metastasis Reviews·David Tarin
Oct 18, 2014·World Journal of Clinical Cases·Keita KaiKohji Miyazaki
Jun 12, 2003·World Journal of Gastroenterology : WJG·Harry Hua-Xinag XiaBenjamin Chun-Yu Wong
Aug 19, 2004·The American Journal of Surgical Pathology·Hiroyuki OsawaKentaro Sugano
Jan 1, 1995·Current Problems in Surgery·H A PittJ L Cameron

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