PMID: 8984028Jun 1, 1996Paper

Mucosal enzyme activity for butyrate oxidation; no defect in patients with ulcerative colitis

Gut
E S AllanA Allan

Abstract

Butyrate is an important energy source for the colon and its metabolism has been reported to be defective in ulcerative colitis. One mechanism for defective butyrate metabolism in patients with ulcerative colitis could be an enzyme deficiency in the beta-oxidation pathway of butyrate. This study was undertaken to measure the activity of each enzyme involved in the beta-oxidation pathway of butyrate in colonic epithelium. Patients with ulcerative colitis (n = 33), Crohn's colitis (n = 10), and control subjects with colorectal cancer or diverticular disease (n = 73) were studied. Analysis was carried out using fluorometric and spectrophotometric techniques on homogenised epithelial biopsy specimens. Significantly increased butyryl CoA dehydrogenase activity was found in mucosa from patients with ulcerative colitis (33.2 (28.3, 38.1) mumol/g wet weight/min:mean (95% CI)) compared with activity in mucosa from control patients (24.3 (20.9, 27.7) mumol/g wet weight/min:mean (95% CI)) p < 0.02. No significant increase in activity of the enzymes butyryl-CoA synthetase, crotonase or hydroxybutyryl-CoA dehydrogenase was found in patients with ulcerative colitis. In contrast the mucosal thiolase activity was significantly lower in those p...Continue Reading

References

Dec 1, 1978·Gut·M R KeighleyJ Alexander-Williams
Sep 2, 1991·Analytical Biochemistry·W LagewegR J Wanders
Jun 9, 1956·British Medical Journal·S C TRUELOVE, W C RICHARDS

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Citations

Sep 24, 2009·Inflammatory Bowel Diseases·Ronan ThibaultJean-Pierre Segain
Nov 21, 1998·Diseases of the Colon and Rectum·M M DuffyP R O'Connell
Feb 28, 2002·Alimentary Pharmacology & Therapeutics·S J HulinM C Eggo
Jan 1, 1996·Inflammatory Bowel Diseases·P R GibsonA J Wilson
Jun 1, 1998·The Veterinary Quarterly·W von EngelhardtR Busche
Apr 21, 2005·Molecular Nutrition & Food Research·Julio GalvezAntonio Zarzuelo
Mar 1, 1997·Baillière's Clinical Gastroenterology·P R Gibson
Dec 30, 1998·The Journal of Nutrition·J W Simpson
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J Jørgensen, P B Mortensen
Mar 19, 2003·European Journal of Clinical Investigation·P VerniaUNKNOWN Gruppo Italiano per lo Studio del Colon and del Retto

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