PMID: 9176072Apr 1, 1997Paper

Mucosal expression and luminal release of epidermal and transforming growth factors in patients with duodenal ulcer before and after eradication of Helicobacter pylori

Gut
P C KonturekE G Hahn

Abstract

Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF alpha) are potent gastric acid inhibitors and stimuli of mucosal growth and protection but their involvement in Helicobacter pylori associated duodenal ulcer has been little examined. To assess gastric acid secretion, plasma gastrin concentrations, mucosal content of EGF and TGF alpha, and mucosal expression of these peptides and their receptor (EGFr) as well as salivary and gastric luminal release of EGF under basal conditions and after pentagastrin stimulation in 10 healthy subjects and in 25 H pylori positive patients with duodenal ulcer before and after two weeks of triple anti-H pylori therapy and four weeks after the termination of this therapy. Pentagastrin stimulation caused a significant increase in salivary and gastric release of EGF both in healthy controls and patients with duodenal ulcers but in the patients, the eradication of H pylori resulted in several fold higher gastric luminal (but not salivary) EGF release than before the anti-H pylori therapy. Mucosal contents of immunoreactive EGF and TGF alpha and mucosal expression of EGF, TGF alpha, and EGFr in H pylori positive patients with duodenal ulcer were significantly higher than those in h...Continue Reading

Citations

Nov 10, 2005·Journal of Endocrinological Investigation·B ElitokZ Kanay
Jul 9, 2005·European Journal of Gastroenterology & Hepatology·Kazimierz RembiaszJerzy Stachura
Oct 13, 1998·Alimentary Pharmacology & Therapeutics·J W KonturekW Domschke
Mar 27, 2007·Best Practice & Research. Clinical Gastroenterology·Larry H Lai, Joseph J Y Sung
Jul 26, 2005·The Journal of Pathology·Matthias P A EbertChristoph Röcken
May 26, 2004·International Journal of Pharmaceutics·G YetkinC Ozoğul
Dec 3, 2014·Brazilian Journal of Otorhinolaryngology·Marco Antonio dos Anjos CorvoIvo Bussoloti Filho
Apr 5, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·M F Dixon
Apr 25, 2013·Seminars in Pediatric Surgery·Kathryn J RowlandBrad W Warner
Aug 24, 2017·Helicobacter·Seong-Hyung ChoiNa Ra Yun
Nov 1, 1998·Journal of Gastroenterology and Hepatology·Jan KonturekWolfram Domschke
Dec 7, 2021·Journal of Agricultural and Food Chemistry·Mengqi LiSongyi Lin

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