PMID: 793953Oct 1, 1976Paper

Mucosal gastrin concentration, molecular forms of gastrin, number and ultrastructure of G-cells in patients with duodenal ulcer

Gut
W CreutzfeldtN S Track

Abstract

The mean antral immunoreactive gastrin (IRG) concentration of 38 duodenal ulcer (DU) patients was significantly higher (35-9+/-5-2 mug/g) than that of 21 controls (15-9+/-2-6 mug/g). Also the mean IRG concentration in the proximal duodenal mucosa of 15 DU patients (3-2+/-0-8 mug/g) was higher (but not significantly) than that of 10 controls (1-8+/-0-5 mug/g). The number of G-cells in the antral mucosa of 58 DU patients and in the duodenal mucosa of 29 DU patients was not larger than that of controls. The distribution of immunoreactivity in gastrin components has been investigated in the antral and duodenal mucosa of six DU patients and six controls. In the antral mucosa the mean percentage of G-17 was 93-3% in DU patients and 92-0% in controls. G-34 amounted to 4-0% in DU patients and to 5-0% in controls. The G-34 percentage in the duodenal mucosa was higher (however not significantly) in the DU patients than in the controls (50-1% versus 35-8%). Ultrastructurally, the antral G-cells of DU patients had a significantly lower density index of their secretory granules suggesting higher functional activity. It is concluded that the exaggerated serum IRG response of DU patients to different stimuli is not a consequence of an increas...Continue Reading

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Citations

Mar 4, 2000·Microscopy Research and Technique·C BordiG Ferraro
Nov 9, 1978·Cell and Tissue Research·N S TrackW Creutzfeldt
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·A J TorresJ L Balibrea
Dec 1, 1978·The American Journal of Digestive Diseases·J H LeeJ D Welsh
Feb 16, 1987·Klinische Wochenschrift·H KoopR Arnold
Jan 1, 1981·The Japanese Journal of Surgery·S NomiyamaS Majima
Jan 1, 1988·The Japanese Journal of Surgery·I YokoyamaH Takagi
Mar 1, 1986·Regulatory Peptides·H SchwartingR Arnold
Dec 5, 1998·Toxicon : Official Journal of the International Society on Toxinology·N H ToppaJ R Cunha-Melo
May 1, 1981·Journal of Clinical Pathology·R L McIntyre, J Piris
Sep 20, 1979·World Journal of Surgery·W Creutzfeldt, R Arnold
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·A GiacosaR Cheli
Jan 1, 1979·Scandinavian Journal of Gastroenterology·M J BastieA Ribet
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·S K Lin, J R Lambert
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·H KoopR Arnold
Jan 1, 1979·Scandinavian Journal of Gastroenterology·O CrivelliG Verme
Nov 1, 1984·Pathology, Research and Practice·M OberholzerR E Ehrsam
Mar 21, 2001·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·M Tzaneva
Jun 1, 1980·The Australian and New Zealand Journal of Surgery·A R AskewA I Vinik
Jun 1, 1984·European Journal of Clinical Investigation·B Petersen, B N Andersen
Jul 1, 1979·Clinics in Endocrinology and Metabolism·R J McFarland
Jan 1, 1979·American Journal of Surgery·D H DunnJ P Delaney
Jan 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B Petersen
Oct 1, 1983·Experimental and Molecular Pathology·M SeilerS Reichlin

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