Mucosal healing progression after acute colitis in mice

World Journal of Gastroenterology : WJG
Sandra Vidal-LletjósAnnaïg Lan

Abstract

Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied. To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis. C57BL/6 male mice were given 3.5% dextran sodium sulfate (DSS) in drinking water for 5 d. They were euthanized 2 (day 7), 5 (day 10), 8 (day 13), and 23 (day 28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory...Continue Reading

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Citations

Aug 19, 2020·European Journal of Nutrition·Sandra Vidal-LletjósAnnaïg Lan
Sep 30, 2020·Cellular and Molecular Gastroenterology and Hepatology·Fatima DaoudSebastian Albinsson

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
dissection
PCR

Software Mentioned

Pannoramic Viewer
house pipeline
lme4
R
RStudio
Histalim
lsmeans
CaseViewer
car

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