Abstract
To study the local host response in patients with colonic and ileal neobladders, with or without bacteriuria. Twenty-three patients with colonic neobladders and 19 with ileal neobladders were included. Eleven radical prostatectomy patients and seven healthy male volunteers were used as controls. Six urine samples were obtained from all patients and controls over a six-month period. The samples were cultured semiquantitatively, and the number of neutrophils and concentrations of the inflammatory mediators interleukin 6 and 8 (IL-6, IL-8) in the urine were determined. The prostatectomy patients and healthy volunteers had sterile urine, and concentrations of IL-6 and IL-8 were below the detection limit. Most (>70%) of the urine samples from patients with colonic and ileal neobladders showed anaerobic or aerobic bacterial growth, and uropathogens were identified in about 45% of the samples. The local host response was minimal or undetectable in the sterile urine samples. However, the host response was markedly induced by uropathogenic strains in the urine, but not by urinary carriage of nonpathogenic or anaerobic strains. IL-8, but not IL-6, was increased in colonic neobladders, which corresponds to the mucosal host responses in pa...Continue Reading
References
Sep 1, 1992·The Journal of Infectious Diseases·S HedgesC Svanborg
Jul 27, 1992·FEBS Letters·M Baggiolini, I Clark-Lewis
Feb 1, 1991·The Journal of Infectious Diseases·P de ManC Svanborg
Apr 1, 1991·The Journal of Experimental Medicine·G D MartichA F Suffredini
Jan 1, 1990·Scandinavian Journal of Urology and Nephrology·W Månsson, S Colleen
May 1, 1989·The Journal of Urology·N G KockM R Mahran
Jun 1, 1989·British Journal of Urology·S AkerlundB M Philipson
May 1, 1987·The Journal of Infectious Diseases·B A LipskyR E Berger
Jun 1, 1987·The Journal of Urology·A Le DucP Teillac
Aug 1, 1986·Mayo Clinic Proceedings·B GoldwasserR C Benson
Feb 1, 1986·The Journal of Urology·W MånssonP A Mårdh
Mar 1, 1971·The Journal of Urology·R F BishopM Gracey
Aug 1, 1994·British Journal of Urology·S AkerlundO Jonsson
Dec 1, 1994·International Archives of Allergy and Immunology·L HangG Andersson
Feb 1, 1993·Infection and Immunity·W AgaceC Svanborg
Dec 8, 1998·The Journal of Infectious Diseases·G OttoC Svanborg
Apr 12, 2001·Cellular Microbiology·B WulltC Svanborg
May 29, 2003·The Journal of Urology·S J KeeganD L Gally
Jul 10, 2003·Infectious Disease Clinics of North America·Björn WulltC Svanborg
Jan 22, 2004·European Urology·Björn WulltWiking Månsson
Citations
Oct 27, 2006·Current Infectious Disease Reports·Ann E Stapleton
Nov 26, 2010·Urology·Claire L TownesJudith Hall
Apr 21, 2009·The Journal of Urology·Pascal ZehnderUrs E Studer
Nov 19, 2013·Urologic Oncology·Roy ManoOfer Yossepowitch
Jul 2, 2016·Journal of Korean Medical Science·Kwang Hyun KimDong Hyeon Lee
Dec 7, 2011·Nature Reviews. Urology·Barbara W Trautner
Sep 29, 2019·World Journal of Urology·Liang G QuNathan Lawrentschuk