Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity.

Frontiers in Immunology
Nicolas MilletMarc Swidergall

Abstract

The fungus Candida albicans colonizes the oral mucosal surface of 30-70% of healthy individuals. Due to local or systemic immunosuppression, this commensal fungus is able to proliferate resulting in oral disease, called oropharyngeal candidiasis (OPC). However, in healthy individuals C. albicans causes no harm. Unlike humans mice do not host C. albicans in their mycobiome. Thus, oral fungal challenge generates an acute immune response in a naive host. Therefore, we utilized C. albicans clinical isolates which are able to persist in the oral cavity without causing disease to analyze adaptive responses to oral fungal commensalism. We performed RNA sequencing to determine the transcriptional host response landscape during C. albicans colonization. Pathway analysis revealed an upregulation of adaptive host responses due to C. albicans oral persistence, including the upregulation of the immune network for IgA production. Fungal colonization increased cross-specific IgA levels in the saliva and the tongue, and IgA+ cells migrated to foci of fungal colonization. Binding of IgA prevented fungal epithelial adhesion and invasion resulting in a dampened proinflammatory epithelial response. Besides CD19+ CD138- B cells, plasmablasts, and p...Continue Reading

References

Sep 1, 1989·Oral Surgery, Oral Medicine, and Oral Pathology·Y L Hernandez, T E Daniels
Feb 1, 1986·International Journal of Oral and Maxillofacial Surgery·H Ben-AryehD Gutman
Dec 1, 1984·Clinical Immunology and Immunopathology·E W CarrowJ E Domer
Oct 1, 1994·The Journal of Infectious Diseases·J JensenE Balish
Feb 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·D W WilliamsM A Lewis
Nov 10, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Nucci, E Anaissie
Feb 27, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·V Cuneyt KalfaE Richard Stiehm
Aug 23, 2006·Current Topics in Microbiology and Immunology·A J Macpherson
Jun 3, 2008·Nature Methods·Ali MortazaviBarbara Wold
Feb 11, 2009·The Journal of Experimental Medicine·Liise-anne Pirofski, Arturo Casadevall
Sep 14, 2011·Current Opinion in Gastroenterology·Andrew J MacphersonKathy D McCoy
Oct 7, 2011·Mucosal Immunology·N J MantisB Corthésy
Mar 10, 2012·Nature Protocols·Norma V Solis, Scott G Filler
Apr 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva BärSalomé LeibundGut-Landmann
Jun 27, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sumit GhoshJane M Schuh
Oct 3, 2012·Current Opinion in Allergy and Clinical Immunology·Anne PuelJean-Laurent Casanova
Dec 20, 2012·Mucosal Immunology·N Hernández-SantosS L Gaffen
Dec 21, 2012·Science Translational Medicine·Gordon D BrownTheodore C White
Mar 15, 2013·Journal of Oral Microbiology·Per Brandtzaeg
Apr 2, 2013·The Journal of Allergy and Clinical Immunology·Atsushi KatoRobert P Schleimer
Jul 23, 2013·Frontiers in Immunology·Blaise Corthésy
Aug 22, 2013·Frontiers in Immunology·Per Brandtzaeg
Jun 22, 2014·Eukaryotic Cell·Marc Swidergall, Joachim F Ernst
Dec 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saswati Panda, Jeak L Ding
Dec 24, 2014·Gut Microbes·Amandine MathiasBlaise Corthésy
Jan 22, 2015·Virulence·Jonathan P Richardson, David L Moyes
Jan 27, 2015·Trends in Immunology·Isioma U EgbuniweKatie E Lacy
Jul 15, 2015·Trends in Immunology·Andrew J MacphersonKathy D McCoy
Oct 3, 2015·PLoS Pathogens·Kerstin Trautwein-WeidnerSalomé LeibundGut-Landmann
Nov 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed F AliEva M Carmona
Nov 21, 2015·Immunity·David M Underhill, Eric Pearlman
May 31, 2016·Cell Host & Microbe·Matthew L WheelerIliyan D Iliev
Jul 20, 2016·Infection and Immunity·Mary Ann Jabra-RizkMairi Noverr
Sep 16, 2016·PLoS Pathogens·Simon AltmeierSalomé LeibundGut-Landmann
Nov 12, 2016·Methods in Molecular Biology·Florian Sparber, Salomé LeibundGut-Landmann
Nov 22, 2016·Journal of Thoracic Disease·Yuanda XuLing Chen
Jan 13, 2017·PLoS Pathogens·Marc Swidergall, Scott G Filler

❮ Previous
Next ❯

Citations

May 1, 2021·Journal of Fungi·Gianluca IngrossoTeresa Zelante
Jun 3, 2021·Journal of Fungi·Tomasz M KarpińskiArtur Adamczak
Jul 16, 2021·Nature·Kyla S OstJune L Round
Nov 18, 2021·Clinical Microbiology Reviews·Fabián SalazarAdilia Warris

❮ Previous
Next ❯

Datasets Mentioned

BETA
PRJNA657562

Methods Mentioned

BETA
RNA-Seq
PCR
confocal microscopy
FACS
differential
fluorescence assay
ELISA
flow cytometry

Software Mentioned

HTseq
FlowJo
Cufflink
clusterProfiler R package
R
SOM
FACS Diva
STAR
Tophat
DESeq2

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Related Papers

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
R D Cannon, W L Chaffin
Advances in Experimental Medicine and Biology
Martinna Bertolini, A Dongari-Bagtzoglou
© 2021 Meta ULC. All rights reserved