Mucosal immune response in newborn Holstein calves that had maternally derived antibodies and were vaccinated with an intranasal multivalent modified-live virus vaccine

Journal of the American Veterinary Medical Association
Kevin L HillPhilip J Griebel

Abstract

To determine whether maternally derived antibodies interfere with the mucosal immune response following intranasal (IN) vaccination of newborn calves with a multivalent modified-live virus vaccine. Randomized controlled clinical trial. 23 newborn Holstein bull calves. Calves received colostrum and were assigned to group A (unvaccinated control calves), group B (IN vaccination on day 0), or group C (IN vaccination on days 0 and 35). Serum and nasal secretion sample (NSS) titers of antibodies specific for bovine herpesvirus 1, bovine viral diarrhea virus 1, and bovine viral diarrhea virus 2; WBC counts; and NSS interferon concentrations were determined up to day 77. Calves had high serum titers of maternally derived antibodies specific for vaccine virus antigens on day 0. High IgA and low IgG titers were detected in NSSs on day 0; NSS titers of IgA decreased by day 5. Group B and C NSS IgA titers were significantly higher than those of group A on days 10 through 35; group C IgA titers increased after the second vaccination. Serum antibody titers decreased at a similar rate among groups of calves. Interferons were not detected in NSSs, and calves did not develop leukopenia. IN vaccination of newborn calves with high concentrations...Continue Reading

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Citations

Aug 3, 2012·Animal Health Research Reviews·Ryan Taschuk, Philip J Griebel
Nov 10, 2012·Biologicals : Journal of the International Association of Biological Standardization·Christopher C L Chase
Apr 5, 2016·Animal Health Research Reviews·Manuel F ChamorroPaul H Walz
Jun 9, 2015·Animal Health Research Reviews·Philip J Griebel
Nov 7, 2017·Annual Review of Animal Biosciences·Rahwa OsmanPhilip Griebel

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