Mucosal immune response to Tropheryma whipplei

International Journal of Medical Microbiology : IJMM
Sabine RingThomas Marth

Abstract

Whipple's disease is a rare infectious disease caused by the ubiquitously occurring Tropheryma whipplei in predisposed persons. Genetic or acquired defects in the mucosal and peripheral immune system become apparent as diminished Th1 immune functions with decreased production of IL-12 and IFN-gamma accompanied by an increased secretion of IL-4. These defects may enable T. whipplei to survive and replicate. The recently established cultivation of the bacterium in HEL cells and the isolation from infected intestinal biopsies enable a multitude of experimental possibilities which may lead to an improved diagnosis as well as understanding of the etiology and pathogenesis of Whipple's disease.

References

Apr 19, 1979·The New England Journal of Medicine·G E FeurleR Waldherr
Oct 1, 1979·European Journal of Clinical Investigation·G E FeurleV Lenhard
Jul 30, 1992·The New England Journal of Medicine·D A RelmanS Falkow
Aug 24, 1991·Lancet·K H WilsonJ A Wilson
Jan 1, 1987·Arthritis and Rheumatism·W O Dobbins
Jun 1, 1988·Scandinavian Journal of Gastroenterology·R BjerknesO D Laerum
Apr 27, 1968·Lancet·J D MaxwellW C Watson
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·D F Keren
Mar 1, 1981·Digestive Diseases and Sciences·W O Dobbins
Feb 9, 1995·The New England Journal of Medicine·W O Dobbins
Jan 1, 1997·Current Opinion in Hematology·G Trinchieri
Jan 1, 1997·Annual Review of Immunology·E A BachR D Schreiber
Sep 18, 1997·The Journal of Infectious Diseases·G SchoedonA Schaffner
Jan 7, 1998·Human Pathology·M EckH K Müller-Hermelink
Feb 17, 1998·Applied and Environmental Microbiology·M MaiwaldA von Herbay
Dec 29, 1998·Annals of Internal Medicine·T SchneiderM Zeitz
Oct 8, 1999·Lancet·S StreetG H Neild
Mar 4, 2000·The New England Journal of Medicine·D RaoultT J Marrie
Jan 4, 2001·Clinical and Diagnostic Laboratory Immunology·F Fenollar, D Raoult
Mar 7, 2001·JAMA : the Journal of the American Medical Association·D RaoultP E Fournier
Mar 23, 2001·The Journal of Infectious Diseases·D N Fredricks, D A Relman
Aug 9, 2001·International Journal of Systematic and Evolutionary Microbiology·B La ScolaD Raoult
Jan 5, 2002·Clinical and Diagnostic Laboratory Immunology·Zhongxing LiangDidier Raoult
Oct 31, 2002·Gastroenterology·Thomas MarthThomas Schneider
Jan 28, 2003·Lancet·Thomas Marth, Didier Raoult
Oct 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·B BLACK-SCHAFFER

❮ Previous
Next ❯

Citations

Jan 26, 2008·Journal of Travel Medicine·Jochen SüssPeter C Werner
Sep 13, 2006·Muscle & Nerve·Marie PugetNathalie Streichenberger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.