PMID: 9525585Apr 3, 1998Paper

Mucosal immunity to herpes simplex virus type 2 infection in the mouse vagina is impaired by in vivo depletion of T lymphocytes

Journal of Virology
M B Parr, E L Parr

Abstract

Intravaginal (IVAG) inoculation of wild-type herpes simplex virus type 2 (HSV-2) in mice causes epithelial infection followed by lethal neurological illness, while IVAG inoculation of attenuated HSV-2 causes epithelial infection followed by development of protective immunity against subsequent IVAG challenge with wild-type virus. The role of T cells in this immunity was studied by in vivo depletion of these cells with monoclonal antibodies. Three groups of mice were used for each experiment: nonimmune/challenged mice, immune/challenged mice, and immune depleted mice [immune mice depleted of a T-cell subset(s) shortly before challenge with HSV-2]. Mice were assessed for epithelial infection 24 h after challenge, virus protein in the vaginal lumen 3 days after challenge, and neurological illness 8 to 14 days after challenge. Monoclonal antibodies to CD4, CD8, or Thy-1 markedly reduced T cells in blood, spleen, and vagina, but major histocompatibility complex class II antigens were still partially upregulated in the vaginal epithelium after virus challenge, indicating that virus-specific memory T-cell function was not entirely eliminated from the vagina. Nevertheless, immune mice depleted of CD4+ and CD8+ T cells, Thy-1+ T cells, ...Continue Reading

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Citations

Aug 8, 2002·Oral Diseases·P L Fidel
Jan 15, 2003·Clinical Microbiology Reviews·David M Koelle, Lawrence Corey
Apr 4, 2007·Expert Review of Anti-infective Therapy·Meghna Ramaswamy, Anna Maria Geretti
Dec 7, 2011·Current Opinion in Infectious Diseases·Amanda J Lee, Ali A Ashkar
Aug 8, 2013·PloS One·Malgorzata KrzyzowskaWanda Stankiewicz
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manoj ThapaDaniel J J Carr
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P HärleD J Carr
Aug 7, 2009·Journal of Virology·Amanda Kwant-MitchellKenneth L Rosenthal
Dec 3, 2008·The Journal of Experimental Medicine·Norifumi IijimaAkiko Iwasaki
Oct 2, 2007·Journal of Leukocyte Biology·Yoshiko KagimotoYasunobu Yoshikai
May 25, 1999·Infection and Immunity·P L FidelF Wormley
Feb 22, 2011·Journal of Reproductive Immunology·Tiffany ChanAli A Ashkar

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