Mucosal melanomas of the head and neck: the role of postoperative radiation therapy.

ISRN Oncology
Kunal SaigalJanet Nguyen-Sperry

Abstract

Objectives. Mucosal melanomas are rarer than their cutaneous counterparts and are associated with a poorer prognosis. We report the clinical outcomes of patients with mucosal melanomas of the head and neck region generally treated with definitive surgery followed by postoperative radiation therapy (RT). Methods. We reviewed the records of 17 patients treated at the University of Miami in 1990-2007. Patients generally received conventionally fractionated RT regimens to the postoperative bed. Elective nodal RT was not routinely delivered. Eight patients received adjuvant chemotherapy or immunotherapy. Results. Median followup was 35.2 months (range 5-225). As the first site of failure: 3 patients recurred locally, 2 regionally and 2 distantly. All 3 patients who recurred locally had not received RT. Of the 5 locoregional recurrences, 4 were salvaged successfully with multimodality therapy with no evidence of disease at last followup. Overall survival was 64.7% at 2 years and 51.5% at 5 years. Conclusions. Patients with mucosal melanoma of the head and neck are best treated with surgery to achieve negative margins, followed by postoperative RT to optimize local control. Elective nodal irradiation may not be indicated in all cases,...Continue Reading

References

Dec 1, 1991·The British Journal of Radiology·D Gilligan, N J Slevin
Sep 1, 1989·Archives of Otolaryngology--head & Neck Surgery·D J HoytS R Fisher
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Sep 8, 2007·Critical Reviews in Oncology/hematology·Marco KrengliRoberto Orecchia
Apr 1, 2008·American Journal of Clinical Oncology·Marcus WagnerWilliam M Mendenhall
Dec 3, 2008·International Journal of Radiation Oncology, Biology, Physics·Takeshi YanagiHirohiko Tsujii

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Citations

Jul 6, 2014·Case Reports in Oncological Medicine·Shahzad AhmadNicholas Masciotra
Dec 18, 2015·Head & Neck·Davide LombardiPiero Nicolai
Nov 26, 2015·Journal of Medical Imaging and Radiation Oncology·Jessica M FrakesJimmy J Caudell
Dec 30, 2014·International Journal of Radiation Oncology, Biology, Physics·Stanislav LazarevRichard Bakst
Oct 9, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michele Del VecchioMichele Maio
Apr 1, 2014·Radiation Oncology·Cody D SchlaffKevin A Camphausen
Nov 20, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ben GreenPeter A Brennan

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Methods Mentioned

BETA
surgical resection
dissection

Software Mentioned

R
SAS

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