PMID: 8100063May 1, 1993Paper

Mucosal neuromas and plexiform neurofibromas: an immunocytochemical study

Pediatric Pathology
J CangiarellaM A Greco

Abstract

Mucosal neuromas (MN), a component of multiple endocrine neoplasia (MEN) type IIb, may be confused histologically with plexiform neurofibromas (PN), a component of neurofibromatosis. The ability to distinguish between these two markers for different genetic diseases is crucial, as the risk of development of medullary thyroid carcinoma and pheochromocytoma in affected patients with MEN IIb is great. We studied two cases each of MN and PN by immunocytochemistry (IC). Epithelial membrane antigen (EMA) proved to be the most useful marker. MN consisted of bundles of disorganized and tortuous nerve fibers surrounded by a thickened perineurium that expressed the cellular phenotype EMA(+), S-100(-). PN consisted of enlarged nerve fascicles with a loose myxoid stroma and was EMA negative. Thus, IC highlighted the differing pattern of growth and histogenesis of the proliferating cells in the two lesions and is likely to be especially useful in those lesions with atypical histology.

References

Jun 1, 1976·Oral Surgery, Oral Medicine, and Oral Pathology·J A CarneyS A Lovestedt
Sep 11, 1990·Journal of Pediatric Surgery·R A DeckerS A Wells
Oct 1, 1990·The British Journal of Oral & Maxillofacial Surgery·M OhishiH Tashiro
Sep 1, 1988·The American Journal of Surgical Pathology·A ArizaJ Rosai
Mar 17, 1988·The New England Journal of Medicine·R L Martuza, R Eldridge

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Citations

May 20, 2003·Auris, Nasus, Larynx·Takatsugu ShimazakiTadashi Nakashima
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Justin M M Cates, Cheryl M Coffin
Feb 24, 2010·Journal of Cutaneous Pathology·Ossama Abbas, Jag Bhawan
Sep 1, 2004·The British Journal of Oral & Maxillofacial Surgery·Kazunari NishiharaMasachika Fujiwara
Aug 1, 1997·Journal of the American Academy of Dermatology·R M PujolJ M de Moragas
May 18, 2019·Pediatric Dermatology·Katherine ThompsonAmanda Moon
Apr 3, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Louis P Dehner, Alejandro A Gru

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