Mucosal protective effects of vitamin E and misoprostol during acute radiation-induced enteritis in rats.

Digestive Diseases and Sciences
L R EmpeyR N Fedorak


Cytotoxic effects of ionizing radiation on gastrointestinal epithelium may be mediated by oxygen free radicals. Therapeutic intervention directed toward oxidant scavenging and increasing tissue oxygen tension may provide a novel approach to management. We investigated the effects of a nonenzymatic oxygen radical scavenger (vitamin E) and an exogenous PGE1 analog known to increase mucosal blood flow (misoprostol) on acute radiation enteritis. Rats were pretreated with: (1) vitamin E, (2) misoprostol, or (3) a combination of both agents prior to 10 Gy abdominal radiation. Three days following irradiation, net fluid absorption using in vivo isolated loops, mucosal histology, and mucosal morphometry using a computerized videoplan were determined in jejunum, ileum, and colon. Nonirradiated control intestine demonstrated net fluid absorption in all segments, which was not altered by vitamin E and/or misoprostol treatment. Irradiation significantly reduced net fluid absorption in jejunum, ileum, and colon. Vitamin E administered prior to irradiation maintained jejunal, ileal, and colonic fluid absorption near control levels. In contrast misoprostol or a combination of vitamin E and misoprostol did not provide protection against the in...Continue Reading


Jul 1, 1987·Journal of Clinical Pathology·L D JubyA T Axon
Nov 1, 1985·Digestive Diseases and Sciences·R L Herting, G A Clay
Apr 1, 1986·The American Journal of Physiology·L MagliolaA W Jones
Apr 1, 1972·The British Journal of Radiology·C A JoslinA Mallik
Sep 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S YoshidaM D Ginsberg
Jun 15, 1982·Biochemical and Biophysical Research Communications·J B MasseyH J Pownall

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