PMID: 8610976Feb 13, 1996Paper

Mucosal tolerance in a murine model of experimental autoimmune encephalomyelitis

Annals of the New York Academy of Sciences
B Metzler, D C Wraith

Abstract

Attempts to induce oral tolerance in a murine model of EAE with either the dominant T-cell epitope or whole protein have failed. These results may, in part, be due to the extraordinarily low affinity for class II MHC displayed by the dominant T-cell epitope. This belief is supported by experiments using a high-affinity analogue of the peptide that was capable of inducing tolerance at a high dose. By contrast, peptide inhalation has proven an effective route for induction of mucosal tolerance in this model. Most importantly, the inhalation of a single peptide could inhibit disease induced by the complex mixture of antigens found in whole myelin. Peptide inhalation was effective both before and after disease induction, and there was a positive correlation between affinity of class II binding and tolerogenicity of a panel of analogues of the N-terminal peptide of myelin basic protein.

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Citations

Mar 4, 1998·Arthritis and Rheumatism·J R Kalden, J Sieper
Oct 11, 2001·Arthritis and Rheumatism·E H ChoyG S Panayi
Dec 29, 1998·Transplantation Proceedings·C BurkhartD C Wraith
Feb 1, 1997·Molecular Medicine Today·P J DelvesI M Roitt
Nov 1, 2008·Nature Reviews. Drug Discovery·Rocio S Lopez-Diego, Howard L Weiner
Jun 3, 2004·Nature Reviews. Immunology·Lloyd Mayer, Ling Shao
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·D TeitelbaumM Sela
Sep 23, 2003·American Journal of Respiratory and Critical Care Medicine·F Runa AliA Barry Kay
Dec 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yong ChenJohn M Hallenbeck
Dec 2, 2005·International Reviews of Immunology·Mireia Sospedra, Roland Martin
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A StefferlC Linington
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheng-Hong WeiLinda A Sherman
Feb 1, 2005·Annals of the New York Academy of Sciences·Emma J O'neillDavid C Wraith

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