PMID: 8610980Feb 13, 1996Paper

Mucosal tolerance to experimental autoimmune myasthenia gravis is associated with down-regulation of AChR-specific IFN-gamma-expressing Th1-like cells and up-regulation of TGF-beta mRNA in mononuclear cells

Annals of the New York Academy of Sciences
C G MaH Link

Abstract

Oral and nasal administration of nicotinic acetylcholine receptor (AChR) to Lewis rats prior to myasthenogenic immunization with AChR and complete Freund's adjuvant (CFA) resulted in prevention or marked decrease of the severity of experimental autoimmune myasthenia gravis (EAMG) and suppression of AChR-specific B-cell responses and of AChR-reactive T-cell function. To examine the involvement of immunoregulatory cytokines and the underlying mechanisms involved in tolerance induction, in situ hybridization with radiolabeled cDNA oligonucleotide proves was adopted to enumerate mononuclear cells (MNC) expressing mRNA for the proinflammatory cytokine interferon-gamma (IFN-gamma), the B cell-stimulating interleukin-4 (IL-4), and the immunosuppressive transforming growth factor-beta (TGF-beta). Popliteal and inguinal lymph nodes from EAMG rats contained elevated numbers of AChR-reactive IFN-gamma, IL-4, and TGF-beta mRNA-expressing cells, compared to control rats receiving PBS orally or nasally and injected with CFA only. Oral and nasal tolerance was accompanied by decreased numbers of AChR-reactive IFN-gamma and IL-4 mRNA-expressing cells and strong up-regulation of TGF-beta mRNA-positive cells in lymphoid organs when compared to no...Continue Reading

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Citations

Mar 4, 1998·Arthritis and Rheumatism·J R Kalden, J Sieper
Dec 13, 1997·Molecular Neurobiology·J Lindstrom
May 29, 2000·Immunology Today·A SaoudiM De Baets
Nov 25, 2000·Journal of the American College of Cardiology·Y WangN R Rose
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Jun 3, 2004·Nature Reviews. Immunology·Lloyd Mayer, Ling Shao
Jul 21, 1998·Annals of the New York Academy of Sciences·J LindstromM Nelson
Jul 21, 1998·Annals of the New York Academy of Sciences·M C SouroujonS Fuchs
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K J BeckerJ M Hallenbeck
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Jul 13, 2002·Respiratory Medicine·S P Newman, W W Busse
Mar 15, 2000·Muscle & Nerve·J M Lindstrom
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N S OstlieB M Conti-Fine
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P I KarachunskiB M Conti-Fine
Dec 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X F Bai, H Link
Jan 29, 2000·Journal of Autoimmunity·G J Prud'homme, C A Piccirillo
Sep 10, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J A KenchD Nemazee
Jan 3, 2001·Journal of the American Society of Nephrology : JASN·John Reynolds, Charles D Pusey

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