Abstract
Proteus mirabilis, a common cause of urinary tract infection (UTI), expresses several types of fimbria including mannose-resistant/Proteus-like fimbriae (MRP), uroepithelial cell adhesin (UCA), renamed non-agglutinating fimbriae (NAF) by some authors, and P. mirabilis fimbriae (PMF), which are potentially involved in adhesion to the uroepithelium. In this study, we immunised different groups of mice with recombinant structural subunits of these fimbriae (MrpA, UcaA and PmfA) using two mucosal routes (nasal and transurethral) and we transurethrally challenged the animals with a P. mirabilis uropathogenic isolate. Induction of specific serum and urine IgG and IgA was measured to assess the potential role of the humoral immune response in protection against experimental ascending P. mirabilis UTI. Intranasally MrpA- and UcaA-immunised mice were protected against P. mirabilis ascending UTI, since recovery of bacteria from kidneys and bladders was significantly lower than in PBS-treated mice, and both fimbrial subunits significantly induced specific serum and urine antibodies. Only MrpA and PmfA transurethrally immunised animals were protected only at the kidney level, and in this case only MrpA-immunised mice exhibited significant ...Continue Reading
References
Aug 1, 1977·The Journal of Infectious Diseases·W E StammJ V Bennett
Sep 1, 1978·The Journal of Pediatrics·C S EdénS Olling
Feb 1, 1979·Journal of Medical Microbiology·B W Senior
May 1, 1987·Mutation Research·K A Eckert, N R Drinkwater
Jan 1, 1987·Gene·A H RosenbergF W Studier
May 5, 1986·Journal of Molecular Biology·F W Studier, B A Moffatt
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Apr 1, 1980·Journal of Clinical Pathology·P LarssonS Olling
May 1, 1994·Microbial Pathogenesis·P ZuninoC Legnani-Fajardo
Mar 1, 1997·Molecular Microbiology·H ZhaoH L Mobley
Aug 1, 1997·European Journal of Biochemistry·Y A KnirelA Rozalski
Apr 17, 1999·Microbiology·H ZhaoH L Mobley
Feb 11, 2000·The Journal of Infectious Diseases·S LangermannS Koenig
Apr 11, 2000·Emerging Infectious Diseases·F W van GinkelJ R McGhee
Sep 19, 2000·Infection and Immunity·H Y WuM W Russell
Oct 12, 2000·FEMS Immunology and Medical Microbiology·P ZuninoD J Maskell
Dec 2, 2000·Microbes and Infection·C CokerH L Mobley
Apr 9, 2001·Clinical Microbiology Reviews·P L OgraR C Welliver
Jul 24, 2002·International Journal of Antimicrobial Agents·Xin Li, Harry L T Mobley
Nov 29, 2002·Current Drug Targets. Infectious Disorders·M J McCluskie, R D Weeratna
May 3, 2003·FEMS Immunology and Medical Microbiology·Rafael PellegrinoPablo Zunino
Nov 6, 2003·Microbiology·Pablo ZuninoDuncan J Maskell
Dec 23, 2003·Infection and Immunity·Xin LiHarry L T Mobley
Nov 24, 2004·Infection and Immunity·Xin LiHarry L T Mobley
Citations
Oct 9, 2012·Nature Reviews. Microbiology·Chelsie E Armbruster, Harry L T Mobley
Jul 16, 2008·Infection and Immunity·Greta R NielubowiczHarry L T Mobley
Sep 2, 2010·Infection and Immunity·Praveen AlamuriHarry L T Mobley
Apr 21, 2011·Infection and Immunity·Melanie M PearsonHarry L T Mobley
Apr 29, 2014·Antonie van Leeuwenhoek·Paola ScavonePablo Zunino
Mar 19, 2011·Journal of Medical Microbiology·Paola ScavonePablo Zunino
Sep 15, 2007·FEMS Immunology and Medical Microbiology·Pablo ZuninoDuncan J Maskell
Jul 21, 2007·FEMS Immunology and Medical Microbiology·Sérgio P D RochaWaldir P Elias
Aug 13, 2011·Vaccine·Yu-Chun LuWen-Jen Yang
Nov 28, 2012·Pathogens and Global Health·Elie K BarbourSteve Harakeh
Apr 8, 2015·Infection and Immunity·Nadine J BodeMelanie M Pearson
Aug 29, 2009·Microbiology and Immunology·Paola ScavonePablo Zunino
Jun 29, 2006·Microbiology·Vanessa SosaPablo Zunino
Feb 27, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Mehri HabibiSaeid Bouzari
Apr 27, 2013·Pathogens and Disease·Rafael PellegrinoPablo Zunino
Aug 8, 2018·Infection and Immunity·Irina DebnathMelanie M Pearson
Jun 2, 2016·Journal of Bacteriology·Nadine J BodeMelanie M Pearson
Feb 10, 2018·EcoSal Plus·Chelsie E ArmbrusterMelanie M Pearson
Mar 22, 2016·Microbiology Spectrum·Valerie P O'BrienScott J Hultgren
Nov 7, 2015·Microbiology Spectrum·Jessica N Schaffer, Melanie M Pearson