Mucosal versus muscle pain sensitivity in provoked vestibulodynia

Journal of Pain Research
Kathryn WitzemanDenniz Zolnoun

Abstract

An estimated 8.3%-16% of women experience vulvovaginal discomfort during their lifetime. Frequently these patients report provoked pain on contact or with attempted intercourse, commonly referred to as provoked vestibulodynia (PVD). Despite the burden of this condition, little is known about its potential etiologies including pelvic floor muscular dysfunction and mucosal components. This knowledge would be beneficial in developing targeted therapies including physical therapy. To explore the relative contribution of mucosal versus muscle pain sensitivity on pain report from intercourse among women with PVD. In this proof of concept study, 54 women with PVD underwent a structured examination assessing mucosal and pelvic muscle sensitivity. We examined three mucosal sites in the upper and lower vestibule. Patients were asked to rate their pain on cotton swab palpation of the mucosa using a 10-point visual analog scale. Muscle pain was assessed using transvaginal application of pressure on right and left puborectalis, and the perineal muscle complex. The Gracely pain scale (0-100) was used to assess the severity of pain with intercourse, with women rating the lowest, average, and highest pain levels; a 100 rating the highest level...Continue Reading

Citations

Jul 13, 2017·Journal of Gynecology Obstetrics and Human Reproduction·M SerrandE Delorme
Sep 9, 2017·Obstetrics and Gynecology·James A Simon, Vanessa A Lukas
Nov 18, 2016·F1000Research·Ahinoam Lev-Sagie, Steven S Witkin
Jan 24, 2019·British Journal of Pain·Anna GhizzaniMattia Fortina
Jun 27, 2019·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
May 2, 2020·Nature Reviews. Disease Primers·Sophie BergeronNina Bohm-Starke
Jul 18, 2020·The Journal of Pain : Official Journal of the American Pain Society·Lydia LoAndrea Rapkin
Apr 13, 2021·Neurourology and Urodynamics·Helena FrawleyJenniffer Voelkl Guevara
Jul 3, 2021·International Journal of Environmental Research and Public Health·Rafael Torres-Cueco, Francisco Nohales-Alfonso
Oct 30, 2016·The Journal of Pain : Official Journal of the American Pain Society·Barbara D ReedAnanda Sen

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