Mucosally transmitted feline immunodeficiency virus induces a CD8+ antiviral response that correlates with reduction of cell-associated virus

The Journal of Infectious Diseases
J G BucciW A Tompkins

Abstract

Intravaginal inoculation of cats with feline immunodeficiency virus (FIV) results in acute systemic infection accompanied by a strong CD8+ immune response that inhibits viral replication. CD8+ anti-FIV activity, revealed by increased FIV replication in peripheral blood mononuclear cells (PBMC) depleted of CD8+ lymphocytes, was detected by 6 weeks after inoculation and correlated with reduced PBMC-associated virus at 12, 16, and 32 weeks after inoculation. Some cats with strong CD8+ anti-FIV activity during acute infection did not seroconvert and yielded no evidence of FIV infection at later times. These data suggest that CD8+ immunity may play a major role in eliminating virus during primary transmucosal FIV infection and may down-regulate viral replication during asymptomatic infection.

Citations

Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rick B Meeker
May 25, 2005·Veterinary Immunology and Immunopathology·Mary Jo Burkhard, Edward A Hoover
Apr 23, 1999·Journal of Reproductive Immunology·H L JordanW A Tompkins
Oct 18, 2001·Veterinary Immunology and Immunopathology·J L ButterworthM B Tompkins
Nov 27, 2002·Vaccine·Mary Jo BurkhardWayne A F Tompkins
May 3, 2000·AIDS Research and Human Retroviruses·L A Obert, E A Hoover
Jan 15, 2002·AIDS Research and Human Retroviruses·M J BurkhardE A Hoover
Feb 13, 2002·AIDS Research and Human Retroviruses·Mary Jo BurkhardEdward A Hoover
Aug 26, 1998·AIDS Research and Human Retroviruses·H L JordanW A Tompkins
Oct 17, 2006·Clinical Microbiology Reviews·Sue VandeWoude, Cristian Apetrei
Oct 30, 2003·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Cornelia J Ketz-RileyMichael T Barrie
Feb 22, 2008·Veterinary Immunology and Immunopathology·Mary B Tompkins, Wayne A Tompkins
Mar 6, 2007·The Veterinary Clinics of North America. Small Animal Practice·P Cynda Crawford, Julie K Levy
Apr 27, 2010·The Veterinary Journal·Nicola F FletcherJohn J Callanan
May 11, 2005·Journal of the American Veterinary Medical Association·P Cynda CrawfordJulie K Levy
Dec 1, 2004·Journal of the American Veterinary Medical Association·Julie K LevyMargaret R Slater
Nov 5, 2003·American Journal of Veterinary Research·Marta E BullWayne A F Tompkins
Sep 23, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sue VandeWoudeEdward A Hoover
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas W VahlenkampWayne A F Tompkins

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