Mucositis: pathobiology and management

Current Opinion in Oncology
Alessandro Villa, S T Sonis

Abstract

Oral mucositis remains a frequent debilitating toxicity associated with drug and radiation regimens used to treat cancer. This review highlights the recent understanding of the biological basis, risk factors for, and management for oral mucositis. Prevalence and incidence data for mucositis are inconsistent and often underreported. The pathogenesis of mucositis encompasses a sequence of biological events possibly influenced by the oral microbiome and environment. Despite its frequency and severity, there is currently no effective treatment available for the majority of patients at risk. However, with the better understanding of the pathogenesis of mucositis a number of new drugs and biological agents are under investigation. Genome-wide risk prediction tools will allow the identification of patients at risk of developing mucositis. Oral mucositis is a common complication of cancer treatment that may negatively impact the patient's cancer treatment outcome. Despite its frequency and consequences, the lack of effective interventions has frustrated patients and caregivers. Fortunately, a broad range of mechanistically targeted compounds are being developed.

Associated Clinical Trials

References

Jul 8, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·M J DoddP Larson
Oct 24, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Stephen T Sonis
Jul 26, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Milanko DjuricLjiljana Jankovic
Jan 20, 2007·Cancer·Dorothy M KeefeUNKNOWN Mucositis Study Section of the Multinational Association of Supportive Care in Cancer and the International Society for Oral
Dec 25, 2007·Dental Clinics of North America·Rajesh V LallaDouglas E Peterson
Feb 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicole BlijlevensUNKNOWN European Blood and Marrow Transplantation Mucositis Advisory Group
Jun 7, 2008·Cancer Biology & Therapy·Richard M LoganDorothy M K Keefe
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher K MurphyStephen T Sonis
Sep 4, 2008·Expert Opinion on Emerging Drugs·Dorothy M KeefeJoanne M Bowen
Feb 24, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Nilza Nelly Fontana LopesMaria Teresa Seixas Alves
Jun 28, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicola PratesiClaudio Orlando
Feb 9, 2012·Lasers in Medical Science·Fernanda G BassoCarlos A de Souza Costa
Mar 9, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hanna R MortensenCai Grau
Oct 12, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ourania Nicolatou-GalitisUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Nov 16, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M NomuraS Sawada
Mar 12, 2013·Nature Medicine·Gangwen HanXiao-Jing Wang
Apr 23, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Noor Al-DasooqiUNKNOWN Mucositis Study Group of Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASC
May 25, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ourania Nicolatou-GalitisUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Nov 8, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M F RaphaelW J E Tissing
Mar 13, 2014·Cancer·Rajesh V LallaUNKNOWN Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Societ
Aug 12, 2014·Expert Opinion on Emerging Drugs·Anna Yuan, Stephen Sonis
Sep 15, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Elizabeth Ann ColemanElias J Anaissie

❮ Previous
Next ❯

Citations

Feb 13, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ragda Abdalla-AslanRakefet Czerninski
Aug 16, 2016·Current Problems in Cancer·Alessandro Villa, Stephen Sonis
Jun 15, 2016·Journal of Medical Microbiology·Eline VanlanckerTom Van de Wiele
Mar 9, 2017·Nature Reviews. Gastroenterology & Hepatology·James L AlexanderJames M Kinross
May 10, 2017·International Journal of Molecular Sciences·Ahmed Esmat Abdel MoneimGermaine Escames
Mar 30, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yih-Lin Chung, Newman N M Pui
Jun 29, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Kittipong OnsengJeffrey Johns
Apr 8, 2016·Journal of Dental Research·R M VasconcelosP M Corby
Jun 18, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ana Gabriela Costa NormandoEliete Neves Silva Guerra
Oct 13, 2017·The American Journal of Hospice & Palliative Care·Sowminya ArikapudiSteven J Baumrucker
Oct 12, 2017·Acta Cirúrgica Brasileira·Viviane Carvalho da SilvaMarcos Rabelo de Freitas
Mar 17, 2018·Current Opinion in Supportive and Palliative Care·Petra C Bachour, Stephen T Sonis
Feb 10, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Thaís Bianca BrandãoAlan Roger Santos-Silva
Nov 3, 2015·Current Oral Health Reports·Sali Al-AnsariJudith E Raber-Durlacher
Jun 20, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Emanuele CeredaRiccardo Caccialanza
Oct 26, 2018·Molecular Nutrition & Food Research·Mensiena B G KiewietPau de Vos
Mar 7, 2019·Phytotherapy Research : PTR·Ana Gabriela Costa NormandoEliete Neves Silva Guerra
Apr 27, 2019·Journal of Gastrointestinal Cancer·Farahnaz JoukarAli Akbar Samadani
May 1, 2019·Brazilian Oral Research·Cláudio Rodrigues Rezende CostaEliete Neves Silva Guerra
Apr 2, 2020·Pharmaceutics·Carmem Jane Ferreira VilarCaroline Addison Carvalho Xavier de Medeiros
Jul 11, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Alina T JaegerRom S Leidner
Jun 2, 2020·Journal of Dental Research·C ChenA D Le
Nov 12, 2015·World Journal of Gastroenterology : WJG·Giuseppe AprileStephen T Sonis
Mar 18, 2016·Current Opinion in Supportive and Palliative Care·Elke Cario
Oct 19, 2016·Cancers of the Head & Neck·Firoozeh SamimAndrei Barasch
Jun 24, 2017·Frontiers in Pharmacology·Marika CinauseroStephen T Sonis
Jan 18, 2018·Experimental Biology and Medicine·Eline VanlanckerTom Van de Wiele
Jul 18, 2018·Nutrients·Mensiena B G KiewietPaul de Vos
Mar 12, 2020·Brazilian Dental Journal·Isabella Lima Arrais RibeiroAna Maria Gondim Valença
Apr 14, 2017·PloS One·Beatriz Fernández-GilGermaine Escames
Jan 13, 2018·Expert Opinion on Investigational Drugs·Stephen T Sonis, Alessandro Villa
Jun 6, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Stéfanie ThiemeManoela Domingues Martins
Aug 20, 2019·Journal of the National Cancer Institute. Monographs·Jean-Luc C MougeotFarah B Mougeot

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Clinical Trials Mentioned

NCT01156142
NCT01385748

Software Mentioned

MuGard

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis