Mucous membrane of respiratory epithelium

Environmental Health Perspectives
L Reid, R Jones

Abstract

Of the eight epithelial cell types of the airway surface epithelium three are secretory, the mucous, serous and Clara cells: the first two are also found in the submucosal glands. Organ culture results indicate that the pattern of control of the surface cells is different from that of the glands. Our recent studies show that in the surface epithelium Clara and serous cells can quickly convert to mucous as do nonsecretory undifferentiated cells. The balance between the various cell types changes with airway level. The type of glycoprotein within the secretory granules is neutral or acid, sialylated or sulfated, and also shows a regional pattern. Homeostasis is maintained in the normal but the equilibrium is quickly upset by a variety of irritants, infection of drugs. Change in pattern of glycoprotein synthesis depends largely on change of granules. The granules at the cell apex change first. The nature and distribution of the various receptor binding sites is significant in patterns of control. This lability occurs in an intact epithelium and whether or not mitotic activity is increased. With irritation tolerance to stimulus develops. Antiinflammatory agents can protect against some of these cellular and intracellular events. Ou...Continue Reading

References

Jan 1, 1977·The Histochemical Journal·G P Roberts
Sep 1, 1977·The Australian and New Zealand Journal of Psychiatry·M FlahertyG Parkers
Jan 1, 1978·British Medical Bulletin·M T Lopez-Vidriero, L Reid
Jan 1, 1978·British Medical Bulletin·R Jones, L Reid
May 1, 1978·British Journal of Haematology·E E KleberR W Charlton
Dec 1, 1978·Experimental and Molecular Pathology·S J Coles, L Reid
Apr 1, 1976·Archives of Biochemistry and Biophysics·G P Roberts
Apr 15, 1972·British Medical Journal·R JonesL Reid
Jun 1, 1972·Experimental and Molecular Pathology·J Sturgess, L Reid
Jan 1, 1964·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C MCCARTHY, L REID
Jun 1, 1978·Journal of Youth and Adolescence·H J Emmerich

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Citations

Jan 1, 1984·Experimental Lung Research·M W Conner, L M Reid
Feb 1, 1988·Environmental Research·T G ChristensenG L Snider
Apr 1, 1989·Medicine, Science, and the Law·I Hill

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