Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.

Advanced Drug Delivery Reviews
Samuel K LaiJustin Hanes

Abstract

Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI) tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including conventional particle-based drug delivery systems, are efficiently trapped in human mucus layers by steric obstruction and/or adhesion. Trapped particles are typically removed from the mucosal tissue within seconds to a few hours depending on anatomical location, thereby strongly limiting the duration of sustained drug delivery locally. A number of debilitating diseases could be treated more effectively and with fewer side effects if drugs and genes could be more efficiently delivered to the underlying mucosal tissues in a controlled manner. This review first describes the tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles. It then reviews the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms, and thereby provide targeted or sustained drug delivery for localized therapies in mucosal tissues.

References

Sep 1, 1975·Journal of Applied Physiology·D B YeatesA C Bryan
Sep 1, 1977·Survey of Ophthalmology·F J Holly, M A Lemp
Jan 1, 1975·Annals of Internal Medicine·M A SacknerA Zapata
Dec 3, 1992·Nature·K R BhaskarJ T LaMont
Jan 1, 1992·Annals of the New York Academy of Sciences·J T Lamont
Apr 1, 1992·Pharmaceutical Research·C M LehrH E Junginger
Jan 15, 1992·Experientia·M A DesaiP Vadgama
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S ShakC L Baker
Dec 1, 1989·The Journal of Pharmacy and Pharmacology·P JaniA T Florence
Oct 1, 1989·Analytical Biochemistry·D J ThorntonI Carlstedt
Mar 1, 1988·The American Review of Respiratory Disease·M A SleighN Liron
Jan 1, 1987·Annals of the New York Academy of Sciences·J E O'MullaneE Tomlinson
Aug 1, 1988·Experimental Eye Research·C C ChaoA Herp
Jan 1, 1987·Annals of the New York Academy of Sciences·L A Sternson
Apr 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·C GalabertE Puchelle
Oct 1, 1986·The Biochemical Journal·J K SheehanI Carlstedt
Jan 1, 1981·Annals of Biomedical Engineering·D B YeatesC S Garrard
Apr 1, 1983·The Biochemical Journal·I CarlstedtL Wingerup
Jan 1, 1984·The Biochemical Journal·J K Sheehan, I Carlstedt
Dec 5, 1980·Biochimica Et Biophysica Acta·R N Rowland, J F Woodley
Jan 1, 1982·The Annals of Occupational Hygiene·D B YeatesC S Garrard
Apr 1, 1981·American Industrial Hygiene Association Journal·G LeikaufM Lippmann
Oct 29, 1981·Nature·A Wada, H Nakamura
Nov 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D B YeatesR E Albert
Jun 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·W M FosterE H Bergofsky
Jun 1, 1995·The Histochemical Journal·L Szentkuti, K Lorenz
Jun 1, 1994·Environmental Health Perspectives·J M Samet, P W Cheng
May 1, 1994·Pharmaceutical Research·C DurrerG Ponchel
May 1, 1994·Pharmaceutical Research·C DurrerG Ponchel
Jan 1, 1993·Journal of Drug Targeting·D SchererJ Kreuter
Mar 18, 1994·Science·R GrefR Langer
Feb 1, 1994·Biophysical Journal·W M SaltzmanR A Cone
Feb 18, 1994·Science·C A VasconcellosT P Stossel
Oct 1, 1993·Physiological Reviews·A AllenE Kivilaakso
Jan 1, 1993·Vaccine·D T O'HaganS J Challacombe
Mar 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C CzerkinskyJ Holmgren
Jun 15, 1996·The Biochemical Journal·D J ThorntonJ K Sheehan

❮ Previous
Next ❯

Citations

Jun 7, 2013·Pharmaceutical Research·Patrick B MemvangaVéronique Préat
Aug 21, 2012·Chinese Journal of Integrative Medicine·An-Guo WuXiao-Ping Lai
Oct 3, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Christian LautenschlägerAndreas Stallmach
Apr 27, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ivan PepićJelena Filipović-Grčić
May 21, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Željka Vanić, Nataša Škalko-Basnet
May 28, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Samantha A MeenachHeidi M Mansour
Jul 3, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andreas Bernkop-Schnürch
Jun 4, 2013·International Journal of Pharmaceutics·Hakon H SigurdssonClaus-Michael Lehr
Sep 11, 2013·International Journal of Pharmaceutics·Martin J O'NeillCaitriona M O'Driscoll
Oct 18, 2011·Bioconjugate Chemistry·Olivia M MerkelThomas Kissel
Jan 2, 2013·Chemical Reviews·Venkat Ratnam DevadasuM N V Ravi Kumar
Jul 26, 2012·Molecular Pharmaceutics·Marygorret ObonyoLiangfang Zhang
Feb 2, 2011·Nano Letters·Kathleen E FischerTejal A Desai
Oct 1, 2011·Chemical Research in Toxicology·Vanesa C SanchezAgnes B Kane
Aug 11, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jung Soo SukJustin Hanes
Jun 12, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Songwen JuHuang-Ge Zhang
Apr 13, 2011·Nanoscale·Michael B Zimmermann, Florentine M Hilty
Nov 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Benjamin C TangJustin Hanes
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Samuel K LaiJustin Hanes
Jun 1, 2010·The Journal of Biological Chemistry·Thejani E RajapaksaDavid D Lo
Jan 28, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Chelsea R NavarretteTodd A Wyatt
Aug 4, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Maria Manuela GasparCarsten Ehrhardt
Jun 16, 2012·Science Translational Medicine·Laura M EnsignJustin Hanes
Nov 16, 2013·International Journal of Nanomedicine·Anne-Claire GrooFrederic Lagarce
Oct 20, 2010·International Journal of Nanomedicine·Rama Mallipeddi, Lisa Cencia Rohan
Nov 4, 2010·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Kristen Bowey, Ronald J Neufeld
Feb 13, 2010·Nanomedicine·Tewodros MamoOmid C Farokhzad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Samuel K LaiJustin Hanes
Advanced Drug Delivery Reviews
Richard Cone
Proceedings of the National Academy of Sciences of the United States of America
Benjamin C TangJustin Hanes
© 2021 Meta ULC. All rights reserved