Mucus-penetrating nanoparticles: Promising drug delivery systems for the photodynamic therapy of intestinal cancer

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Juliane AnderskiKlaus Langer

Abstract

Photodynamic therapy (PDT) is an auspicious therapy approach for the treatment of cancer. Despite its numerous benefits, the drug delivery of the used photosensitizer (PS) to target locations inside the human body remains a main therapy challenge, since the standard intravenous PS injection often causes systemic side-effects. To circumvent this therapy drawback, the oral application represents a promising administration alternative. Especially for the treatment of intestinal cancer it offers the possibility of a local treatment with a reduced likelihood for adverse drug reactions. To establish a suitable drug delivery system for intestinal PDT, we developed nanoparticles (NP) of the biodegradable and biocompatible polymer poly(lactic-co-glycolic) acid (PLGA), loaded with the model PS 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP). By functionalizing the particle surface with either poly(ethylene glycol) (PEG) or chitosan (CS), mucus-penetrating or mucoadhesive properties were obtained. These particle characteristics are important to enable an overcoming of the intestinal mucus barrier and thus lead to a PS accumulation close to and in the target cells. In permeation studies with a biosimilar mucus and in cell culture exp...Continue Reading

Citations

Feb 6, 2020·Journal of Cellular and Molecular Medicine·Luisa SeguellaGiovanni Sarnelli
Feb 20, 2021·Nature Communications·Louis William RogowskiMin Jun Kim
Mar 4, 2021·Journal of Nanoscience and Nanotechnology·Rossana TerraccianoGuido Pagana
Mar 2, 2021·International Journal of Pharmaceutics·Liu LiuXiaoqin Chu
Oct 5, 2021·Frontiers in Bioengineering and Biotechnology·Letícia B SilvaPriscyla D Marcato

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