Muller "Elements" in Drosophila : How the Search for the Genetic Basis for Speciation Led to the Birth of Comparative Genomics

Genetics
Stephen W Schaeffer

Abstract

The concept of synteny, or conservation of genes on the same chromosome, traces its origins to the early days of Drosophila genetics. This discovery emerged from comparisons of linkage maps from different species of Drosophila with the goal of understanding the process of speciation. H. J. Muller published a landmark article entitled Bearings of the "Drosophila" work on systematics, where he synthesized genetic and physical map data and proposed a model of speciation and chromosomal gene content conservation. These models have withstood the test of time with the advent of molecular genetic analysis from protein to genome level variation. Muller's ideas provide a framework to begin to answer questions about the evolutionary forces that shape the structure of the genome.

References

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Citations

Jan 24, 2020·G3 : Genes - Genomes - Genetics·Ryan BracewellDoris Bachtrog
May 22, 2020·Evolution; International Journal of Organic Evolution·Carl E HjelmenJohn Spencer Johnston
Dec 10, 2019·Annual Review of Animal Biosciences·Caroline B Albertin, Oleg Simakov
Aug 28, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juan M Murillo-Maldonado, Juan R Riesgo-Escovar
Jul 2, 2021·Science Advances·Sarah B CareyStuart F McDaniel
May 9, 2021·Molecular Biology and Evolution·Claire MérotLouis Bernatchez
Feb 3, 2022·Science Advances·Oleg SimakovDaniel S Rokhsar

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Methods Mentioned

BETA
dissection
chromosomal aberrations
electrophoresis

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