Multi-biomarker responses in the freshwater mussel Dreissena polymorpha exposed to polychlorobiphenyls and metals

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Melissa FariaCarlos Barata

Abstract

Contaminant related changes in behavioral, phase I and II metabolizing enzymes and pro-oxidant/antioxidant processes in the freshwater mussels Dreissena polymorpha exposed to metals and PCBs were assessed. Behavioral and biochemical responses including filtering rates, key phase I, II and antioxidant enzymes and levels of metallothioneins, glutathione, lipid peroxidation and DNA strand breaks were determined in digestive glands of mussels after being exposed to sublethal levels of mercury chloride, methyl mercury, cadmium and Aroclor 1260 during 5 days. In 7 out of 12 responses analyzed, mussels showed significant differences across treatments. Unusual properties of measured ethoxyresorufin-O-deethylase (EROD) activities indicated that mussels lack an inducible CYP1A enzymatic activity. Despite of using similar exposure levels, inorganic and organic mercury showed different biomarker patterns of response with methyl mercury being more bio-available and unable to induce metallothionein proteins. Mussels exposed to Cd presented higher levels of metallothioneins and an enhanced metabolism of glutathione, whereas those exposed to Aroclor showed their antioxidant glutathione peroxidase related enzyme activities inhibited. Although t...Continue Reading

References

Aug 23, 1976·Biochemical and Biophysical Research Communications·R A Lawrence, R F Burk
Jan 1, 1991·Free Radical Biology & Medicine·H EsterbauerH Zollner
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·C S Jewell, G W Winston
Jan 1, 1985·Methods in Enzymology·I Carlberg, B Mannervik
Jan 1, 1988·Environmental and Molecular Mutagenesis·P L Olive
Feb 1, 1995·Free Radical Biology & Medicine·S J Stohs, D Bagchi
Oct 3, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J Engelken, A Hildebrandt
Aug 24, 2000·Critical Reviews in Toxicology·J J WhyteD E Tillitt
Oct 20, 2000·Analytical Biochemistry·H KamencicB H Juurlink
Sep 7, 2004·Archives of Environmental Contamination and Toxicology·N HanariM B Berg
Jun 28, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Montserrat Solé, David R Livingstone
Jan 13, 2006·Ecotoxicology and Environmental Safety·Francesco RicciardiAlfredo Provini
Jul 15, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Véronique MarieAlain Boudou
Sep 13, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·A BinelliA Provini
Jun 15, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·A BinelliA Provini
Jun 21, 2007·Journal of Analytical Toxicology·Sergi DíezJosep M Bayona

❮ Previous
Next ❯

Citations

Sep 20, 2012·Environmental Science and Pollution Research International·María Fernández-SanjuanCarlos Barata
Oct 18, 2013·Environmental Science and Pollution Research International·Changhui LiuVictor W C Chang
Feb 25, 2014·Ecotoxicology and Environmental Safety·Luciana F OliveiraClaudia B R Martinez
Jun 23, 2010·Archives of Environmental Contamination and Toxicology·Analu Egydio JacominiPierina Sueli Bonato
Sep 23, 2014·Ecotoxicology and Environmental Safety·Xuxu DengFengxiao Hu
Dec 25, 2012·Ecotoxicology and Environmental Safety·Halina I FalfushynskaOksana B Stoliar
Oct 13, 2012·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yan FangLibing Zhang
Dec 17, 2011·Ecotoxicology and Environmental Safety·Vanessa BurmesterClaudia Wiegand
Apr 15, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Consuelo RivaAlfredo Provini
Jan 2, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yan FangMuyan Chen
Jun 2, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·A BinelliA Provini
Jul 22, 2014·Environmental Toxicology·Stefano MagniAndrea Binelli
Mar 31, 2015·The Science of the Total Environment·Miguel Cañedo-ArgüellesBen Kefford
Apr 10, 2013·The Science of the Total Environment·Anna NavarroBenjamin Piña
Jul 6, 2014·The Science of the Total Environment·Hrönn Ólína JörundsdóttirHalldór Pálmar Halldórsson
Oct 19, 2010·Environmental Pollution·Anna NavarroBenjamin Piña
Jun 30, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lin WangJingjing Miao
Oct 22, 2013·The Science of the Total Environment·Melissa FariaCarlos Barata
Sep 4, 2012·The Science of the Total Environment·Victoria OchoaCarlos Barata
Apr 22, 2014·The Science of the Total Environment·Isa D L GomesMelissa Faria
Jul 17, 2016·The Science of the Total Environment·Eva-Maria LummerJuergen Geist
Aug 11, 2010·Free Radical Biology & Medicine·José M MatésJavier Márquez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.