Multi-centre phase II clinical trial of yttrium-90 resin microspheres alone in unresectable, chemotherapy refractory colorectal liver metastases.

British Journal of Cancer
M CosimelliItalian Society of Locoregional Therapies in Oncology (SITILO)

Abstract

This multi-centre phase II clinical trial is the first prospective evaluation of radioembolisation of patients with colorectal liver metastases (mCRC) who failed previous oxaliplatin- and irinotecan-based systemic chemotherapy regimens. Eligible patients had adequate hepatic, haemopoietic and renal function, and an absence of major hepatic vascular anomalies and hepato-pulmonary shunting. Gastroduodenal and right gastric arteries were embolised before hepatic arterial administration of yttrium-90 resin microspheres (median activity, 1.7 GBq; range, 0.9-2.2). Of 50 eligible patients, 38 (76%) had received > or =4 lines of chemotherapy. Most presented with synchronous disease (72%), >4 hepatic metastases (58%), 25-50% replacement of total liver volume (60%) and bilateral spread (70%). Early and intermediate (>48 h) WHO G1-2 adverse events (mostly fever and pain) were observed in 16 and 22% of patients respectively. Two died due to renal failure at 40 days or liver failure at 60 days respectively. By intention-to-treat analysis using Response Evaluation Criteria in Solid Tumours, 1 patient (2%) had a complete response, 11 (22%) partial response, 12 (24%) stable disease, 22 (44%) progressive disease; 4 (8%) were non-evaluable. Medi...Continue Reading

References

Mar 17, 2001·Statistics in Medicine·R P A'Hern
Feb 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B GrayV Gebski
Mar 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles S FuchsJ Randolph Hecht
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Dec 2, 2004·Surgical Oncology·Graeme J Poston
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Andrew S KennedyCinthia Drachenberg
May 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Andrew S KennedyScott Sailer
Jul 22, 2006·Annals of Surgery·Sylvain ManfrediAnne-Marie Bouvier
Feb 9, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J FerlayP Boyle
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce J GiantonioUNKNOWN Eastern Cooperative Oncology Group Study E3200
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemRafael G Amado
May 12, 2007·Surgical Oncology·Donald C McMillan, Colin S McArdle
May 29, 2007·Surgical Oncology·Vijay P KhatriNicholas J Petrelli
Jul 17, 2007·Lancet·Matthew T SeymourUNKNOWN National Cancer Research Institute Colorectal Clinical Studies Group
Sep 27, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E DeutschM Ducreux
Sep 6, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemM Peeters
Jan 22, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Bassel AtassiRiad Salem
Apr 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alberto F SobreroHoward A Burris
Jul 29, 2008·Journal of Vascular and Interventional Radiology : JVIR·Tobias F JakobsMaximilian F Reiser
Oct 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hansjochen WilkeSalvatore Siena

❮ Previous
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Citations

May 17, 2014·World Journal of Gastroenterology : WJG·Jae Seon EoDong Soo Lee
Dec 6, 2014·Future Oncology·Benjamin Garlipp, Christiane J Bruns
Dec 6, 2014·Future Oncology·Andrew Kennedy
Jan 31, 2013·Radiology·Andreas H MahnkenThierry de Baère
Jan 12, 2012·The Oncologist·Nicholas ZdenkowskiStephen Ackland
Nov 18, 2011·Radiology Research and Practice·Siobhan B O'NeillMichael M Maher
Mar 27, 2012·Expert Opinion on Therapeutic Targets·Maurizio CosimelliCarlo Ludovico Maini
Dec 15, 2015·Expert Review of Anticancer Therapy·May ChoMarwan Fakih
Jul 19, 2014·Expert Review of Gastroenterology & Hepatology·Andrew J PageTimothy M Pawlik
Jan 16, 2013·Expert Opinion on Drug Delivery·Anima Vats, Kamla Pathak
Mar 5, 2016·Expert Review of Anticancer Therapy·Andrew S Kennedy
Mar 19, 2013·Journal of Experimental & Clinical Cancer Research : CR·Elisa MelucciUNKNOWN Italian Society of Locoregional Therapies in Oncology (S.I.T.I.L.O.)
Nov 29, 2013·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·D HippsJ J French
Apr 22, 2016·Current Treatment Options in Oncology·Bippan Singh SanghaRobert J Lewandowski
May 11, 2016·The British Journal of Radiology·Tatjana Gruber-RouhThomas J Vogl
Oct 18, 2016·Expert Review of Anticancer Therapy·Axel AndresChristian Toso
Nov 7, 2014·American Journal of Clinical Oncology·Sanjeeva P KalvaLawrence S Blaszkowsky
Jan 30, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·K M GovaertI H M Borel Rinkes
Feb 27, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Thierry de BaereDavid Malka
Nov 22, 2016·The Cancer Journal·Joseph R KalliniRiad Salem
Jul 30, 2014·World Journal of Hepatology·Francisco Igor B Macedo, Tafadzwa Makarawo
Jun 2, 2016·World Journal of Radiology·Andreas H Mahnken
Jun 24, 2017·World Journal of Clinical Oncology·Giammaria FiorentiniStefano Guadagni
Feb 16, 2018·Journal of Surgical Oncology·Christoph JustingerMichael R Schön
May 17, 2018·Cardiovascular and Interventional Radiology·I KurilovaConstantinos T Sofocleous
Oct 30, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Amir SabetSamer Ezziddin
Mar 13, 2014·Cardiovascular and Interventional Radiology·Max SeidenstickerJens Ricke
Jun 18, 2011·Abdominal Imaging·Thierry de Baere, Frederic Deschamps
Nov 1, 2011·Cardiovascular and Interventional Radiology·Ricarda SeidenstickerJens Ricke
Mar 21, 2013·Cardiovascular and Interventional Radiology·Andreas H MahnkenTobias F Jakobs
Feb 16, 2013·Wiener medizinische Wochenschrift·Johannes PetersenWerner Jaschke
Sep 6, 2014·Annals of Surgical Oncology·Leonard R HenryRoderich E Schwarz

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Methods Mentioned

BETA
biopsy
X-ray
surgical resection

Software Mentioned

SPSS

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