Multi-class, multi-residue liquid chromatography/tandem mass spectrometry screening and confirmation methods for drug residues in milk

Rapid Communications in Mass Spectrometry : RCM
Sherri B TurnipseedKeith E Miller

Abstract

This paper describes the development and optimization of a multi-residue veterinary drug screening method for whole milk. The drug residues of regulatory interest in milk include beta-lactams, sulfonamides, tetracyclines, fluoroquinolones, and macrolides. Milk samples were extracted with acetonitrile and the samples were then subjected to a clean-up procedure using a bonded solid-phase extraction cartridge and a molecular weight cut-off filter. Liquid chromatography/tandem mass spectrometry (LC/MS/MS) triple quadrupole electrospray methods were developed to monitor for the drugs in milk. Since established tolerance levels are set for most of these drugs in milk, the initial screening procedure was semi-quantitative, where samples were compared to the response of a positive control. The positive control, consisting of an extract from a portion of milk fortified with the drugs at half their allowed levels, was used to set the laboratory's minimum response criteria for unknown samples. Confirmatory analyses, with additional ion transitions for each residue, were performed on the same extracts.

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Citations

Jul 28, 2009·Analytical and Bioanalytical Chemistry·María Cruz Moreno-BondiErika Rodriguez
Jan 27, 2010·Analytical and Bioanalytical Chemistry·José Luis Martínez VidalRoberto Romero-González
Apr 10, 2010·Analytical and Bioanalytical Chemistry·Alida A M StolkerCláudia P B Martins
Jun 12, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiao-Lin HouTing Yang
Feb 3, 2011·Journal of Agricultural and Food Chemistry·Sherri B TurnipseedKeith E Miller
Aug 21, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M Gaugain-JuhelP Sanders
Oct 13, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·L JankT M Pizzolato
Oct 3, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Katerina BousovaKlaus Mittendorf
Dec 19, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·C RobertPh Delahaut
Apr 9, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Scarlett BiselliLutz Hartig
Sep 28, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Jia ZhanZhi-qiang Huang
May 21, 2008·Analytical and Bioanalytical Chemistry·A A M StolkerM W F Nielen
Jul 18, 2009·Analytical and Bioanalytical Chemistry·Sara Bogialli, Antonio Di Corcia
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Aug 5, 2016·Journal of Mass Spectrometry : JMS·Simone MorettiRoberta Galarini
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Sep 16, 2018·Analytical and Bioanalytical Chemistry·Christin HelmschrodtAngelika Richter

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