Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment

Frontiers in Chemistry
Vincent P SicaTimothy R Baker

Abstract

Demands for increased analytical rigor have been growing within the botanical and dietary supplement industry due to concerns relative to safety, efficacy, and quality. Adulteration, ambiguous definitions, and insufficient perspective on safety are some of the major issues that arise when selecting a botanical extract. Herein, our comprehensive analytical approach is detailed for the selection of grape seed extracts. This approach provided characterization for the constituents above a threshold of toxicological concern by subjecting the extract to UHPLC-UV-CAD-HRMS and GC-FID & GC-HRMS. Thus, constituents within a wide range of volatility were evaluated. Furthermore, the extract was compared to authenticated botanical materials to confirm that no adulteration took place and was also compared to other grape seed extract sources to confirm that the material falls within the general profile. Finally, these data were cleared via an in silico safety assessment based on the list of constituents above the threshold of toxicological concern.

References

Dec 20, 1999·Journal of Agricultural and Food Chemistry·B LabarbeM Moutounet
Apr 17, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J YamakoshiM Kikuchi
Jul 27, 2002·Analytical Chemistry·Roy W Dixon, Dominic S Peterson
May 21, 2005·Phytochemistry·Ronald L Prior, Liwei Gu
Dec 18, 2007·Molecular Nutrition & Food Research·Patricia M Aron, James A Kennedy
Jun 11, 2008·Journal of Agricultural and Food Chemistry·Nils KöhlerPeter Winterhalter
Dec 10, 2008·Molecular Nutrition & Food Research·Wolfgang Hümmer, Peter Schreier
May 14, 2009·Molecular Nutrition & Food Research·José SerranoFulgencio Saura-Calixto
Apr 30, 2010·Database : the Journal of Biological Databases and Curation·V NeveuA Scalbert
Oct 5, 2010·Nutrition Reviews·Julia PetersonMarjorie L McCullough
Jun 17, 2011·Journal of Agricultural and Food Chemistry·Liya Li, Navindra P Seeram
Jun 1, 2012·Journal of Agricultural and Food Chemistry·Fernando Sánchez-PatánBegoña Bartolomé
Oct 10, 2013·Database : the Journal of Biological Databases and Curation·Joseph A RothwellAugustin Scalbert
Jul 18, 2014·Journal of Agricultural and Food Chemistry·Long-Ze LinJames M Harnly
Oct 10, 2014·International Journal of Toxicology·Monice M FiumeF Alan Andersen
Apr 22, 2016·Journal of Agricultural and Food Chemistry·Yongqiang LiuNavindra P Seeram
Jul 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jinhua LiRui Zeng
Feb 14, 2017·Journal of Chromatography. a·Evan M HetrickDonald S Risley
Mar 8, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Karen M VanderMolenCatherine Mahony
Jul 13, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jason G LittleCatherine Mahony

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Citations

Oct 1, 2020·Foods·Jose Manuel SilvanAdolfo J Martinez-Rodriguez
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dimitris MichailidisAlexios Léandros Skaltsounis
Mar 19, 2021·Journal of the American Society for Mass Spectrometry·Robert J StrifeSafa Motlagh
May 18, 2021·3 Biotech·Amita AjitPrashanth Varkey
Oct 10, 2021·Plant Foods for Human Nutrition·Kateřina DadákováJiří Sochor

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Methods Mentioned

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