Multi-dimensional Coding by Basolateral Amygdala Neurons

Neuron
Pinelopi KyriaziDenis Pare

Abstract

Conditioned appetitive and aversive responses (CRs) are thought to result from the activation of specific subsets of valence-coding basolateral amygdala (BLA) neurons. Under this model, the responses of BLA cells to conditioned stimuli (CSs) and the activity that drives CRs are closely related. We tested the strength of this correlation using a task where rats could emit different CRs in response to the same CSs. At odds with this model, the CS responses and CR-related activity of individual BLA cells were separable. Moreover, while the incidence of valence-coding cells did not exceed chance, at the population level there was similarity between valence coding for CSs and CRs. In fact, both lateral and basolateral neurons concurrently encoded multiple task features and behaviors. Thus, conditioned emotional behaviors may not depend on the recruitment of single cells that explicitly encode individual task variables but from multiplexed representations distributed across the BLA.

Citations

Oct 13, 2018·The Journal of Comparative Neurology·Alon AmirDenis Paré
Jan 19, 2019·Science·Gregory CorderGrégory Scherrer
Apr 20, 2019·Science·Jan GründemannAndreas Lüthi
Sep 3, 2020·ELife·Jeremiah K MorrowKatalin M Gothard
Mar 7, 2019·Journal of Neurophysiology·Alon AmirDenis Paré
May 28, 2019·Reviews in the Neurosciences·Francisco Almeida
Feb 6, 2019·Nature Reviews. Neuroscience·Kent C Berridge
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May 1, 2019·Proceedings of the National Academy of Sciences of the United States of America·Donald PfaffWulf Haubensak
Nov 25, 2020·Journal of Neurochemistry·Kaitlin E SullivanMark S Cembrowski
Jul 19, 2019·Neuron·Drew B HeadleyDenis Paré
Dec 15, 2020·Journal of Neuroscience Research·Blake A KimmeyGregory Corder
Feb 18, 2021·Behavioural Brain Research·Adam T BrockettMatthew R Roesch
Mar 5, 2021·Nature·Maria Sol FustiñanaAndreas Lüthi
Jan 21, 2020·Neuron·Yoav LivnehMark L Andermann
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Aug 18, 2021·Molecular Psychiatry·Limeng HuangJ Julius Zhu
Jan 7, 2022·Science·J CourtinA Lüthi

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