Multi-drug resistance genes in the management of neoplastic disease

Journal of Veterinary Internal Medicine
J Stewart, N T Gorman

Abstract

P-gp can function as an ATP-dependent cytotoxic drug-efflux pump. In normal tissues, protein expression is localized to cell surfaces that face excretory lumina; hence, P-gp may function as a toxic-waste disposal system. Tumors that are derived from these tissues can be high expressors of P-gp, and these tumors tend to display intrinsic chemoresistance. Other non-expressing tumors can become P-gp positive after treatment or at relapse, suggesting that mdr may be involved in acquired resistance. The use of MDR-modifying agents has had some clinical success, and further trials of chemosensitizers are proceeding. P-gp overexpression does not explain how clinical resistance to anthracyclines, alkylating agents, and cis-platinum can arise simultaneously. In these cases, multiple genetic mechanisms of resistance may coexist. Eventually, mdr status can be used to select the most effective chemotherapy protocol for the individual. Currently, conversion of a previously mdr negative tumor to mdr expression, in the face of clinical resistance, justifies changing to a non-MDR drug protocol, or if not feasible, the use of MDR sensitizers.

References

Nov 11, 1976·Biochimica Et Biophysica Acta·R L Juliano, V Ling
Mar 1, 1975·Biochemical Pharmacology·W A BleyerV T Oliverio
Feb 1, 1990·Trends in Biochemical Sciences·I C West
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A T FojoI Pastan
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F ThiebautM C Willingham
Nov 2, 1988·Journal of the National Cancer Institute·M M Gottesman
Sep 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M W DeGregorioV J Wiebe
Nov 1, 1989·The Australian and New Zealand Journal of Surgery·J A SmithJ P Collins
Mar 1, 1989·Japanese Journal of Cancer Research : Gann·H TsudaM Terada
Jan 18, 1989·Journal of the National Cancer Institute·L J GoldsteinG M Brodeur
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Cordon-CardoJ R Bertino
Feb 1, 1989·Biochemical Pharmacology·T McGrathM S Center
Apr 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M M Gottesman, I Pastan
Apr 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W S DaltonS E Salmon
Mar 1, 1989·Scientific American·N Kartner, V Ling
May 3, 1989·Journal of the National Cancer Institute·S E SalmonW S Dalton
Jun 21, 1989·Journal of the National Cancer Institute·M Rothenberg, V Ling
Jun 21, 1989·Journal of the National Cancer Institute·B A Chabner, A Fojo
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H L PearceW T Beck
Jul 15, 1989·International Journal of Cancer. Journal International Du Cancer·E Hofsli, J Nissen-Meyer
Sep 1, 1989·Molecular and Cellular Biology·J E ChinI B Roninson
Jan 1, 1989·Advances in Enzyme Regulation·D NiethammerH Probst
Apr 19, 1989·Journal of the National Cancer Institute·R K Jain
Mar 1, 1989·Cancer Treatment Reviews·D J Stewart, W K Evans
Jan 1, 1989·Advances in Cancer Research·A M van der Bliek, P Borst
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L B RussellM D Shelby
Aug 2, 1989·Journal of the National Cancer Institute·S L LaiA F Gazdar
Sep 20, 1989·Journal of the National Cancer Institute·J BourhisG Riou
Nov 2, 1988·Journal of the National Cancer Institute·R K Burt, S S Thorgeirsson
Sep 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J H GerlachR M Baker

❮ Previous
Next ❯

Citations

Aug 5, 2008·Journal of the American Veterinary Medical Association·Erin O BanninkJoyce E Obradovich
Nov 13, 2010·Journal of Cellular and Molecular Medicine·Dan-Dan FengYue-Qin Chen
Jan 1, 1995·The Veterinary Clinics of North America. Small Animal Practice·M C McEntee
Feb 10, 2018·Current Medicinal Chemistry·Guillermo VirkelAdrián Lifschitz
Mar 29, 2013·Journal of the American Animal Hospital Association·Ravinder S DhaliwalNikolaos G Dervisis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.