Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Michelle HeslerYvonne Kohl

Abstract

Nanoplastics (NP) and microplastics (MP) accumulate in our environment as a consequence of the massive consumption of plastics. Huge knowledge-gaps exist regarding uptake and fate of plastic particles in micro- and nano-dimensions in humans as well as on their impact on human health. This study investigated the transport and effects of 50 nm and 0.5 μm COOH-modified polystyrene (PS) particles, as representatives for NP and MP, in different biological models in vitro. Acute toxicity and potential translocation of the particles were studied at the human intestinal and placental barrier using advanced in vitro co-culture models. Furthermore, embryotoxicity and genotoxicity were investigated as highly sensitive endpoints. Polystyrene was not acutely toxic in both sizes (nano- and microparticles). No transport across the intestinal and placental barrier but a cellular uptake and intracellular accumulation of PS nano- and microparticles were determined. The particles were identified as weak embryotoxic and non-genotoxic. In contrast to single-organ studies, this multi-endpoint study is providing a data-set with the exact same type of particles to compare organ-specific outcomes. Our study clearly shows the need to investigate other t...Continue Reading

Citations

Jun 28, 2020·Archives of Toxicology·Josefa DomenechConstanza Cortés
Mar 1, 2020·International Journal of Environmental Research and Public Health·Cheryl Qian Ying YongBor Luen Tang
Dec 12, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Laura RubioAlba Hernández
Oct 17, 2020·The Science of the Total Environment·Amrita Banerjee, Weilin L Shelver
Jan 4, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Frederikke Emilie Heddagaard, Peter Møller
Dec 3, 2020·International Journal of Environmental Research and Public Health·Andreas BrachnerWinfried Neuhaus
Dec 15, 2020·The Science of the Total Environment·Arifur RahmanJaroslav Slobodnik
Mar 17, 2021·Environmental Science & Technology·Nur Hazimah Mohamed NorAlbert A Koelmans
Jun 20, 2020·The Science of the Total Environment·Gurusamy Kutralam-MuniasamyV C Shruti
Mar 27, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Shahla ShojaeiHagar I Labouta
Apr 21, 2021·Journal of Toxicology and Environmental Health. Part a·Eşref Demir
May 1, 2021·Nature Nanotechnology·Denise M MitranoBernd Nowack
Apr 25, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Sara MatthewsElvis Genbo Xu
Jun 3, 2021·International Journal of Environmental Research and Public Health·Giuseppa VisalliAngela Di Pietro
Jun 20, 2021·Advanced Biology·Julia A BoosAndreas Hierlemann
Jul 3, 2021·Pharmaceutics·Thorsten BraunBettina Liebmann
Aug 5, 2021·Journal of Food Protection·Amrita Banerjee, Weilin L Shelver
Aug 5, 2021·Scientific Reports·Julia RudolphRuth Freitag
Sep 10, 2021·Particle and Fibre Toxicology·Ponnusamy Manogaran GopinathNatarajan Chandrasekaran
Nov 30, 2021·Environmental Science. Processes & Impacts·Hassan Khalid AgeelMohamed Abou-Elwafa Abdallah

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