Multi-host transmission dynamics of Schistosoma japonicum in Samar province, the Philippines.

PLoS Medicine
Steven RileyS T McGarvey

Abstract

Among the 6.7 million people living in areas of the Philippines where infection with Schistosoma japonicum is considered endemic, even within small geographical areas levels of infection vary considerably. In general, the ecological drivers of this variability are not well described. Unlike other schistosomes, S. japonicum is known to infect several mammalian hosts. However, the relative contribution of different hosts to the transmission cycle is not well understood. Here, we characterize the transmission dynamics of S. japonicum using data from an extensive field study and a mathematical transmission model. In this study, stool samples were obtained from 5,623 humans and 5,899 potential nonhuman mammalian hosts in 50 villages in the Province of Samar, the Philippines. These data, with variable numbers of samples per individual, were adjusted for known specificities and sensitivities of the measurement techniques before being used to estimate the parameters of a mathematical transmission model, under the assumption that the dynamic transmission processes of infection and recovery were in a steady state in each village. The model was structured to allow variable rates of transmission from different mammals (humans, dogs, cats, ...Continue Reading

References

May 22, 2002·Acta Tropica·Lydia R LeonardoGemiliano D L Aligui
Sep 29, 2005·International Journal for Parasitology·H CarabinUNKNOWN Schistosomiasis Transmission And Ecology In The Philippines Step Project
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Apr 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Song LiangRobert C Spear

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Citations

Aug 19, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark W Robinson, John P Dalton
Dec 2, 2015·Scientific Reports·Neil D YoungRobin B Gasser
May 1, 2012·PLoS Neglected Tropical Diseases·Roger K PrichardSara Lustigman
Apr 9, 2010·Clinical Microbiology Reviews·Donald P McManusAllen G Ross
May 1, 2012·PLoS Neglected Tropical Diseases·María-Gloria BasáñezThomas S Churcher
Sep 15, 2015·PLoS Neglected Tropical Diseases·Ricardo J Soares MagalhãesArchie C A Clements
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·James W RudgeMaría-Gloria Basáñez
Aug 19, 2015·Mathematical Biosciences and Engineering : MBE·Chunxiao DingHuaiping Zhu
Mar 23, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Joycelyn C Jumawan, Leonardo A Estaño
Jul 1, 2021·Acta Biotheoretica·Solomon KadalekaJean M Tchuenche
Aug 19, 2011·Veterinary Parasitology·James V ConlanPaul N Newton

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