Multi-indication and Combination Pricing and Reimbursement of Pharmaceuticals: Opportunities for Improved Health Care through Faster Uptake of New Innovations

Applied Health Economics and Health Policy
Ulf Persson, J M Norlin

Abstract

Many pharmaceuticals are effective in multiple indications and the degree of effectiveness may differ. A product-based pricing and reimbursement system with a single price per product is insufficient to reflect the variable values between different indications. The objective of this article is to present examples of actual pricing and reimbursement decisions using current value-based pricing in Sweden and to discuss their implications and possible solutions. The value of several cancer drugs was estimated for various indications based on a willingness-to-pay threshold of 1 million SEK (EUR 104,000) per QALY gained. For some drugs, the estimated value was higher than the drug acquisition cost in several indications, whilst in others, the estimated value was lower than the drug acquisition cost. Drugs used in combination present a special case. If a drug prolongs survival and consequently also a continued use of the anchor drug, the combination use may not be cost effective even at a zero price. In a product-based pricing and reimbursement system, patients may not get access to drugs or access may be delayed and manufacturers may be discouraged to invest in future indications. To overcome these issues, there are several approache...Continue Reading

References

Jul 25, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Louis P Garrison, David L Veenstra
Jul 30, 2009·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Ulf PerssonKnut Odegaard
Dec 8, 2009·Basic & Clinical Pharmacology & Toxicology·Kari FuruHenrik Toft Sørensen
Jun 5, 2010·BMJ : British Medical Journal·James Raftery
Feb 1, 2009·Journal français d'ophtalmologie·O OuhadjM T Nouri
Mar 26, 2014·Applied Health Economics and Health Policy·Josh J CarlsonLouis P Garrison
Oct 4, 2014·JAMA : the Journal of the American Medical Association·Peter B Bach
Jan 18, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Andrea NavarriaFilippo Drago
Jun 27, 2015·Applied Health Economics and Health Policy·Ulf Persson, Bengt Jönsson
Oct 16, 2016·Blood·S Vincent Rajkumar, Jean Luc Harousseau
Apr 19, 2017·Journal of Midwifery & Women's Health·Nancy A Niemczyk
Jul 13, 2017·Journal of Comparative Effectiveness Research·Steven D PearsonAdrian Towse
Aug 15, 2017·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·S OlofssonU Persson

❮ Previous
Next ❯

Citations

Mar 21, 2018·PharmacoEconomics Open·Paula K Lorgelly
Oct 28, 2018·Applied Health Economics and Health Policy·Dominik J Wettstein, Stefan Boes
Sep 17, 2019·Applied Health Economics and Health Policy·Carlos Campillo-ArteroMarta Trapero-Bertran
Nov 2, 2019·Health Economics, Policy, and Law·Jessica PaceWendy Lipworth
Sep 11, 2018·PharmacoEconomics·Jorge Mestre-FerrandizÁlvaro Hidalgo-Vega
Feb 6, 2020·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Helen O'DonnellCathal Walsh
Nov 14, 2020·International Journal of Environmental Research and Public Health·Rick A VremanWim G Goettsch
Aug 27, 2021·Journal of Market Access & Health Policy·R LawlorA Roediger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved