Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery.

Cell Stem Cell
Arun SharmaClive N Svendsen

Abstract

Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease modeling and have unlocked new possibilities for understanding the mechanisms governing human biology, physiology, and genetics. However, hiPSC-derivatives have traditionally been utilized in two-dimensional monocultures, in contrast to the multi-systemic interactions that influence cells in the body. We will discuss recent advances in generating more complex hiPSC-based systems using three-dimensional organoids, tissue-engineering, microfluidic organ-chips, and humanized animal systems. While hiPSC differentiation still requires optimization, these next-generation multi-lineage technologies can augment the biomedical researcher's toolkit and enable more realistic models of human tissue function.

References

Nov 22, 2007·Science·Junying YuJames A Thomson
Jun 13, 2008·Nature·Declan Butler
Feb 15, 2011·The Journal of Clinical Investigation·Kazim H NarsinhJoseph C Wu
Mar 26, 2011·Stem Cells and Development·Jessica DiasIgor I Slukvin
Apr 15, 2011·Nature·Kristen J BrennandFred H Gage
Apr 26, 2011·Annual Review of Biomedical Engineering·M B EschM L Shuler
Apr 26, 2011·Biomaterials·Aijun WangSong Li
May 13, 2011·Science Translational Medicine·Hua LiuYoon-Young Jang
Sep 3, 2011·Tissue Engineering. Part a·Jessica A DeQuachKaren L Christman
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Satoshi NoriHideyuki Okano
Jan 27, 2012·Nature·Mason A IsraelLawrence S B Goldstein
Jul 28, 2012·Drugs·Yaman KaakehJames E Tisdale
Jan 17, 2013·The Journal of Investigative Dermatology·Ophelia VeraitchManabu Ohyama
May 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe Maria de PeppoDarja Marolt
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Florence ClavagueraMarkus Tolnay
Jun 6, 2013·The International Journal of Biochemistry & Cell Biology·Chengjuan QuMikko J Lammi
Jul 6, 2013·Lab on a Chip·John P WikswoWilliam J Matloff
Jul 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rekha SamuelRakesh K Jain
Sep 3, 2013·Nature·Madeline A LancasterJuergen A Knoblich
Sep 21, 2013·Stem Cell Reports·William J AdamsGuillermo García-Cardeña
Oct 19, 2013·The Journal of Clinical Investigation·Mahboobe GhaediLaura E Niklason
Nov 19, 2013·Nature Cell Biology·Yun XiaJuan Carlos Izpisua Belmonte
Dec 10, 2013·Cell Stem Cell·Justine D MillerLorenz Studer
Jun 11, 2014·Nature Communications·Xiufeng ZhongM Valeria Canto-Soler
Jun 16, 2014·Nature Methods·Paul W BurridgeJoseph C Wu
Aug 6, 2014·Nature Biotechnology·Sangeeta N Bhatia, Donald E Ingber

❮ Previous
Next ❯

Citations

Jun 26, 2020·Current Protocols in Stem Cell Biology·Jeffrey X ZhangJoseph C Wu
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Pilar MonteroManuel M Mazo
Jun 21, 2020·Current Cardiology Reports·Arun Sharma
Oct 7, 2020·Brain : a Journal of Neurology·Polyxeni NikolakopoulouAnna Herland
Oct 17, 2020·Frontiers in Molecular Biosciences·Marco LucianiVasco Meneghini
Oct 22, 2020·International Journal of Molecular Sciences·Lin JiangYigang Wang
Nov 2, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Oliver TruslerAndrew L Laslett
Oct 11, 2020·Drug Discovery Today·Wenjing XuanQingguo Xu
Jan 11, 2021·Development, Growth & Differentiation·Wendy L Thompson, Takanori Takebe
Dec 19, 2020·Nature Reviews. Gastroenterology & Hepatology·Albert GoughD Lansing Taylor
Feb 15, 2021·Journal of Neuroscience Research·Paul M HollowayMichele Zagnoni
Dec 16, 2020·Cell Death and Differentiation·Wouter H van der ValkKarl R Koehler
Jan 15, 2021·International Journal of Molecular Sciences·Margit RosnerMarkus Hengstschläger
Mar 5, 2021·Frontiers in Cardiovascular Medicine·Crystal C KennedyGeorge A Truskey
Mar 16, 2021·IScience·Pamela L GraneyGordana Vunjak-Novakovic
Dec 24, 2020·Small·Ellen FritscheKatharina Koch
Apr 27, 2021·Experimental Biology and Medicine·Passley Hargrove-GrimesDanilo A Tagle
May 1, 2021·Pharmaceuticals·Megan A YamoahXiao-Dong Zhang
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Juan HuangBingying Zhou
May 8, 2021·Stem Cell Research & Therapy·Dandan ZhaoShijun Hu
Jun 5, 2021·Cell Stem Cell·Daniel Naveed TavakolGordana Vunjak-Novakovic
Jul 25, 2021·International Journal of Molecular Sciences·Dawid SkoczekNeli Kachamakova-Trojanowska
Aug 8, 2021·International Journal of Molecular Sciences·Mengmeng JinAndreas Hermann
Sep 4, 2021·Cell Stem Cell·Robin J Kleiman, Sandra J Engle
Aug 25, 2020·Cell Reports Medicine·Arun SharmaClive N Svendsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Organoids in Disease Modeling

Brain organoids are three-dimensional cell culture models derived from human pluripotent stem cells. Since they resemble the embryonic brain, they can be used to help study brain biology, early brain development, and brain diseases. Discover the latest research on brain organoids in disease modeling here.