Multi-matrix system mesalamine: to use or not to use

The Annals of Pharmacotherapy
Pramodini B Kale-PradhanSheila M Wilhelm

Abstract

To evaluate the role of Multi-Matrix System (MMX) mesalamine in the treatment of ulcerative colitis (UC). Literature was obtained through searches of MEDLINE (1966-October 2007) and a bibliographic review of published articles. Key terms used in the searches included ulcerative colitis, mesalamine, MMX, SPD476, and Lialda. All English-language articles that were identified through the search were evaluated. All primary literature was included in the review. The standard treatment for the induction and maintenance of remission in patients with mild-to-moderate UC is aminosalicylate products (mesalamine, sulfasalazine, balasalazide, olsalazine). Current mesalamine formulations are not ideal for long-term treatment due to issues with patient adherence secondary to complex dosing regimens and high pill burden. Clinical studies show that MMX mesalamine achieves clinical and endoscopic remission more frequently compared with placebo or mesalamine enema. Patients receiving MMX mesalamine achieved statistically significant clinical and endoscopic remission when compared with those taking placebo (34.1% vs 12.9%; p < 0.001 with 2.4 g/day vs placebo, and 29.2% vs 12.9%; p = 0.009 with 4.8 g/day vs placebo). Similarly, in another study, s...Continue Reading

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Jul 3, 2010·Expert Review of Clinical Immunology·Arik DahanEllen M Zimmermann
Nov 9, 2010·Journal of the American Academy of Nurse Practitioners·Jill Olmstead
Nov 2, 2012·The Annals of Pharmacotherapy·Bryan L Love, April D Miller
Nov 6, 2008·Inflammatory Bowel Diseases·Siew C Ng, Michael A Kamm
Nov 18, 2008·European Journal of Gastroenterology & Hepatology·Zunwu Zhang, Hugh Kennedy

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