Nov 15, 2019

Multi-Omic Biological Age Estimation and Its Correlation With Wellness and Disease Phenotypes: A Longitudinal Study of 3,558 Individuals

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
John C EarlsNathan D Price

Abstract

Biological age (BA), derived from molecular and physiological measurements, has been proposed to better predict mortality and disease than chronological age (CA). In the present study, a computed estimate of BA was investigated longitudinally in 3,558 individuals using deep phenotyping, which encompassed a broad range of biological processes. The Klemera-Doubal algorithm was applied to longitudinal data consisting of genetic, clinical laboratory, metabolomic, and proteomic assays from individuals undergoing a wellness program. BA was elevated relative to CA in the presence of chronic diseases. We observed a significantly lower rate of change than the expected ~1 year/year (to which the estimation algorithm was constrained) in BA for individuals participating in a wellness program. This observation suggests that BA is modifiable and suggests that a lower BA relative to CA may be a sign of healthy aging. Measures of metabolic health, inflammation, and toxin bioaccumulation were strong predictors of BA. BA estimation from deep phenotyping was seen to change in the direction expected for both positive and negative health conditions. We believe BA represents a general and interpretable "metric for wellness" that may aid in monitorin...Continue Reading

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Mentioned in this Paper

Study
Longitudinal Studies
Toxin
Chronic Disease
Laboratory
Monitoring - Action
Aging
Inflammation
Bioaccumulation
Proteomic Profiling

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