Multi-omics in high-grade serous ovarian cancer: Biomarkers from genome to the immunome

American Journal of Reproductive Immunology : AJRI
Cole CliffordMadhuri Koti

Abstract

Epithelial ovarian cancer (EOC) is a lethal gynaecological disease that imposes significant burden on health care and patient quality of life. High-grade serous carcinoma of the ovary (HGSC) is the most prevalent histological type of EOC. A vast majority of HGSC cases are diagnosed at late stages of the disease, limiting the opportunity for clinical intervention and resulting in a 10-year survival rate of <20%. Recent innovations in high-throughput molecular analysis of patient-derived specimens may address these clinical challenges by providing an enhanced understanding of the molecular aetiology of ovarian cancer, in addition to offering several opportunities for rational biomarker and targeted therapy discovery. In this review, we highlight the most significant contributions of omics approaches and how the advent of immunomics can aid in personalized combination chemo-immunotherapy in ovarian cancer treatment. We further provide insights into immunogenomic correlates of pre-treatment tumour immune microenvironment and some of the potential interpretations of immunomic data that require further validation, based on stromal and immune contributions to biomarker signatures. We believe a comprehensive integrative approach via me...Continue Reading

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Citations

Apr 2, 2019·Expert Opinion on Biological Therapy·Youngwoo ChoMansoor M Amiji
Jan 12, 2021·Frontiers in Cellular and Infection Microbiology·Huanrong LiFengxia Xue
Aug 11, 2021·International Immunology·Keisuke Watanabe, Hiroyoshi Nishikawa
May 15, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lingling TongXiaochun Sun

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