Abstract
The aim of the study is to verify the effect of hyperglycemia on ischemia-reperfusion injury and to explore the feasibility of noninvasive observation of ischemic-reperfusion injury in hyperglycemic ischemic stroke by MRI technique. According to the duration of ischemia and blood glucose levels, 40 rats were divided into hyperglycemic ischemic 2-hr (H-I2h), hyperglycemic ischemic 6-hr (H-I6h), non- hyperglycemic ischemic 2-hr (NH-I2h), and non- hyperglycemic ischemic 6-hr (NH-I6h) groups. T2W imaging, DW imaging, T2 mapping, T2* mapping, DCE, and T1 mapping after enhancement sequences were acquired before reperfusion and approximately 3-hr after reperfusion. ADC, T1, T2, T2*, and Ktrans values of ischemic lesion were obtained in different groups. After reperfusion, the variation of ADC values showed no significant difference between groups with diabetes and groups without diabetes and between different recanalization time-points (2-hr vs 6-hr). After reperfusion, T2, T2*, and Ktrans values increased in different degrees in all four groups. Only the T1 value decreased in all groups. The change of all parameters in groups with hyperglycemia was more obvious than that in groups without hyperglycemia and was more obvious in groups ...Continue Reading
References
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
May 21, 1998·Brain Research·N C HuangJ A Helpern
Oct 2, 1998·Stroke; a Journal of Cerebral Circulation·G A RosenbergJ E Dencoff
Apr 26, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Quan JiangMichael Chopp
Dec 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J M StarrI Marshall
Aug 19, 2003·Neuroradiology·C FitzekJ R Reichenbach
Jul 14, 2004·Archives of Internal Medicine·Thomas AlmdalHenrik Vestergaard
Aug 2, 2005·Neuroscience Letters·Philip A BarberUrsula Tuor
Jun 29, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sharyl R Martini, Thomas A Kent
Mar 6, 2007·European Journal of Radiology·Feng ChenYicheng Ni
Aug 6, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Deepu R PillaiFelix Schlachetzki
Aug 12, 2009·PloS One·Saeid TaheriGary A Rosenberg
Jan 29, 2011·Journal of the American Society of Hypertension : JASH·Akiko SakataMasatsugu Horiuchi
Apr 2, 2011·Stroke; a Journal of Cerebral Circulation·Kunjan R DaveAntonello Pileggi
May 5, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Qiang ShenTimothy Q Duong
May 25, 2011·Neurology·J PutaalaT Tatlisumak
Oct 18, 2011·Annals of Neurology·Seok Joon WonRaymond A Swanson
Apr 29, 2014·Neuroscience·G DingQ Jiang
Sep 28, 2014·Acta Radiologica·Yan Mei YangXiaoYuan Feng
Nov 28, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gongjun TanFaqing Tang
Jul 22, 2015·Journal of Computer Assisted Tomography·Wei-Yuan HuangXiang-Rong Yu
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michael J KnightRisto A Kauppinen
Dec 30, 2015·PloS One·Nuria Muñoz-RivasAna López-de-Andrés
May 1, 2016·Magnetic Resonance Imaging·Wei-Yuan HuangXiang-Rong Yu
Feb 17, 2017·PloS One·Zamir MeraliAndrea Kassner