Multi-scale, tailor-made heart simulation can predict the effect of cardiac resynchronization therapy

Journal of Molecular and Cellular Cardiology
Jun-Ichi OkadaSeiryo Sugiura

Abstract

The currently proposed criteria for identifying patients who would benefit from cardiac resynchronization therapy (CRT) still need to be optimized. A multi-scale heart simulation capable of reproducing the electrophysiology and mechanics of a beating heart may help resolve this problem. The objective of this retrospective study was to test the capability of patient-specific simulation models to reproduce the response to CRT by applying the latest multi-scale heart simulation technology. We created patient-specific heart models with realistic three-dimensional morphology based on the clinical data recorded before treatment in nine patients with heart failure and conduction block treated by biventricular pacing. Each model was tailored to reproduce the surface electrocardiogram and hemodynamics of each patient in formats similar to those used in clinical practice, including electrocardiography (ECG), echocardiography, and hemodynamic measurements. We then performed CRT simulation on each heart model according to the actual pacing protocol and compared the results with the clinical data. CRT simulation improved the ECG index and diminished wall motion dyssynchrony in each patient. These results, however, did not correlate with the...Continue Reading

References

Mar 27, 2012·Cellular and Molecular Bioengineering·Takumi WashioToshiaki Hisada

❮ Previous
Next ❯

Citations

Jan 13, 2018·Journal of Cardiovascular Translational Research·Angela W C LeeSteven A Niederer
Apr 15, 2018·Circulation. Arrhythmia and Electrophysiology·Peter R HuntjensPierre Bordachar
Oct 27, 2018·Nature Reviews. Cardiology·Steven A NiedererNatalia A Trayanova
Jan 7, 2020·PloS One·Paolo Di AchilleViatcheslav Gurev
Jan 21, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Mohammad AlbatatIlangko Balasingham
Mar 11, 2020·Annals of Biomedical Engineering·Taro KariyaToshiaki Hisada
Aug 7, 2018·Frontiers in Physiology·Haibo NiEleonora Grandi
Jul 15, 2020·The Journal of Physiological Sciences : JPS·Jun-Ichi OkadaSeiryo Sugiura
Sep 10, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jun-Ichi OkadaToshiaki Hisada
Mar 20, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hirotada MasudaYoshiki Sawa
Oct 8, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Cesare CorradoSteven A Niederer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.