Jul 1, 2008

Multi-site voxel-based morphometry: methods and a feasibility demonstration with childhood absence epilepsy

Heath R PardoeGraeme D Jackson


Voxel-based morphometry analysis of neurological disorders would benefit if it could use data acquired from different scanners, but scanner based contrast variation could interfere with the detection of disease-specific structural abnormalities. In this study we examine MRI data from three different sites to investigate structural differences between childhood absence epilepsy (CAE) subjects and controls. T1-weighted structural MRI scans were acquired from: Site A. 10 CAE, 213 controls; Site B. 15 CAE, 33 controls; and Site C. 19 CAE, 11 controls. The images were processed using the optimised VBM protocol. Three statistical analyses were undertaken: (1) Comparisons of CAE subjects and controls stratified by site. (2) Between-site comparison of controls from each site. (3) Factorial analysis of all data with site and disease status as factors. Consistent regions of structural change, located in the thalamic nuclei, were observed in the within-site analysis of CAE vs controls. Analysis of control scans, however, indicated site-specific differences between controls, which required that we adjust for site in combined analyses. Analysis of all data with adjustment for site confirmed the finding of thalamic atrophy in CAE cases. Comb...Continue Reading

Mentioned in this Paper

Biologic Segmentation
Thalamic Nuclei
Morphometric Analysis
Chromosome Aberrations
Epilepsy, Absence, Atypical
COIL gene
Absence Epilepsy
Magnetization Transfer Contrast Imaging
Entire Thalamus

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