Multi-spectroscopic methods investigation on the interaction of tenoxicam with DNA

Luminescence : the Journal of Biological and Chemical Luminescence
Bing-Mi LiuBin Liu

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) show chemopreventive and chemosuppressive effects on various cancer cell lines. They exert anticancer activities by inhibiting both at the protein level and/or at the transcription level. Thus, in this paper, the interaction between tenoxicam (TXM) and calf thymus DNA (ct-DNA) was investigated by UV-visible light, fluorescence, viscosity experiments and DNA melting studies. The results showed that TXM could bind to ct-DNA in the groove binding mode. The binding constants were 7.67 × 10(3) and 5.48 × 10(3) M(-1) at 293 and 300 K, respectively. Furthermore, the calculated thermodynamic parameters suggested that hydrogen bonds or van der Waals force might play an important role in the binding of TXM to ct-DNA. The obtained results should give new insight into the pharmacological activity of TXM.

References

Oct 1, 1973·Photochemistry and Photobiology·E A BursteinM N Ivkova
Dec 14, 1999·Japanese Journal of Cancer Research : Gann·N SakusabeT Suzuki
Jan 23, 2003·Bioorganic & Medicinal Chemistry·Stefania MazziniRosanna Mondelli
Sep 27, 2005·Research in Veterinary Science·Birgitt WolfesbergerMonika Egerbacher
Jan 19, 2006·The Journal of Small Animal Practice·C KnottenbeltD J Argyle
May 11, 2006·Journal of Inorganic Biochemistry·Sujata RoyMunna Sarkar
Aug 15, 2008·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mehrnaz Gharagozlou, Davar M Boghaei
Jun 18, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J S MandevilleH A Tajmir-Riahi
Jul 20, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy· MudasirHidenari Inoue
Sep 21, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Nahid ShahabadiMehdi Pourfoulad
Jul 24, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Nahid Shahabadi, Leila Heidari
Aug 29, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Zohreh SattarJamshidkhan Chamani
Dec 19, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sreeja ChakrabortyMunna Sarkar
Feb 25, 2014·International Journal of Biological Macromolecules·Daniel AgudeloHeidar-Ali Tajmir-Riahi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved