PMID: 11332538May 3, 2001Paper

Multi-stage model estimates of lung cancer risk from exposure to diesel exhaust, based on a U.S. railroad worker cohort

Risk Analysis : an Official Publication of the Society for Risk Analysis
S V Dawson, G V Alexeeff

Abstract

A California Environmental Protection Agency (Cal/EPA) report concluded that a reasonable and likely explanation for the increased lung cancer rates in numerous epidemiological studies is a causal association between diesel exhaust exposure and lung cancer. A version of the present analysis, based on a retrospective study of a U.S. railroad worker cohort, provided the Cal/EPA report with some of its estimates of lung cancer risk associated with diesel exhaust. The individual data for that cohort study furnish information on age, employment, and mortality for 56,000 workers over 22 years. Related studies provide information on exposure concentrations. Other analyses of the original cohort data reported finding no relation between measures of diesel exhaust and lung cancer mortality, while a Health Effects Institute report found the data unsuitable for quantitative risk assessment. None of those three works used multistage models, which this article uses in finding a likely quantitative, positive relations between lung cancer and diesel exhaust. A seven-stage model that has the last or next-to-last stage sensitive to diesel exhaust provides best estimates of increase in annual mortality rate due to each unit of concentration, for...Continue Reading

Citations

Jul 15, 2006·Cancer Causes & Control : CCC·Francine LadenEric Garshick
Aug 27, 2002·Environmental Health Perspectives·George D Leikauf
Sep 25, 2010·Journal of the Air & Waste Management Association·Nora TravissMelinda Dawn Treadwell
Jan 30, 2014·International Journal of Environmental Research and Public Health·Yi SunMarkus Mattenklott
Jun 22, 2001·Journal of the Air & Waste Management Association·A C Lloyd, T A Cackette
Jun 30, 2009·Inhalation Toxicology·Markus Roller
Nov 5, 2005·Risk Analysis : an Official Publication of the Society for Risk Analysis·Gretchen StevensJames K Hammitt
Nov 23, 2006·Annals of the New York Academy of Sciences·Markus Roller, Friedrich Pott
Apr 11, 2015·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kenny S CrumpRoger McClellan
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Jun 2, 2016·The Onderstepoort Journal of Veterinary Research·Noluvuyo R MagadlaBruce Gummow
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May 7, 2003·Environmental Science & Technology·Joshua T CohenJonathan I Levy

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