Multi-step regulation of innate immune signaling by Kaposi's sarcoma-associated herpesvirus

Virus Research
Hye-Ra LeeJae U Jung

Abstract

The innate immune system provides an immediate and relatively non-specific response to infection with the aim of eliminating the pathogen before an infection can be fully established. Activation of innate immune response is achieved by production of pro-inflammatory cytokines and type I interferon (IFN). The IFN response in particular is one of the primary defenses utilized by the host innate immune system to control pathogen infection, like virus infection. Hence, viruses have learned to manipulate host immune control mechanisms to facilitate their propagation. Due to this, much work has been dedicated to the elucidation of the Kaposi's sarcoma-associated herpesvirus (KSHV)-mediated immune evasion tactics that antagonize a host's immune system. This review presents our current knowledge of the immune evasion strategies employed by KSHV at distinct stages of its life cycle to control a host's immune system with a focus on interferon signaling.

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Citations

Dec 10, 2016·Virologica Sinica·Hang GaoQiming Liang
Mar 28, 2017·Biochemical and Biophysical Research Communications·Sung-Woo HwangHye-Ra Lee
Mar 21, 2018·Cancers·Timsy UppalSubhash C Verma
Oct 31, 2017·PLoS Pathogens·Nishi R SharmaZhi-Ming Zheng
Sep 24, 2016·Current Opinion in HIV and AIDS·Priscila H GoncalvesRobert Yarchoan
Nov 30, 2018·Retrovirology·Viviane Martha Santos de MoraisMaria Rosângela Cunha Duarte Coêlho

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